Author(s)

Guillaume Mahamat Abderraman^1*, Ibrahim Hamat¹, Zeinabou Maiga Moussa Tondi², Ahmed Tall Lemrabott³, Maria Faye³, Cisse Mouhamadou Moustapha³, Kossi Akomola Sabi⁴, Ka Elhaj Fary Ka³, Niang Abdou³, Diouf Boucar³

¹Hemodialysis Unit, Hôpital Général de Référence Nationale (HGRN), N’Djamena, Tchad.
²Medical Department, FSS/ Université Abdou Moumouni de Niamey, Service de Néphrologie et Hémodialyse, Hôpital National Lamordé de Niamey, Niamey, Niger.
³Nephrology service, Hôpital Aristide Le Dantec de Dakar, Dakar, Sénégal.
⁴Nephrology and Hemodialysis Service, CHU SO Lomé, Lomé, Togo.

Introduction: Hyperuricemia is defined as a level of serum uric acid greater than or equal to 70 mg/l (420 μmol/l) in men and 60 mg/l (360 μmol/l) in women. Several studies have shown that it is a risk factor or a factor of progression of chronic kidney disease. Recent experimental and epidemiological data correlate the association of hyperuricemia with chronic kidney disease (CKD), arterial hypertension and cardiovascular diseases, thus raising the question of the usefulness of therapeutics in the prevention of renal diseases. The objective of this study is to seek a link between chronic kidney disease and hyperuricemia. Materials and Methods: This is a descriptive and analytical study conducted at hemodialysis unit and cardiology service of General Hospital of National reference of N’Djamena (Chad) from 1^th January to 1^th October 2013 (10 months). We included all chronic kidney disease patients hospitalized in hemodialysis unit and cardiology service who presented associated hyperuricemia. Results: There were 712 CKD patients who were hospitalized. Among them, there were 108 patients who were included in the study and who had hyperuricemia as a prevalence of 15.20%. The average age of patients was 35.5 years and the sex ratio was 3/1. The age group between 40 to 60 years represented 54.6%. There were 41.7% of traders. Hypertensive patients accounted for 49.1%; association of diabetes and hypertension was noted in 12.90%. Renal insufficiency was moderate in 43.5% of patients. Hyperuricemia was present in more than 90% of patients. Profession, age, hematuria, proteinuria and hypertension were statistically positively related to hyperuricemia. Treatment consisted of prescribing allopurinol in 84% of patients. In more than 11% of patients the progression was unfavorable. Conclusion: The implication of hyperuricemia in chronic kidney disease has been proved in several recent studies. However, randomized studies at very long scales have to be carried out to conclude from its real impact on the prevention and treatment of chronic kidney disease.

Component, Formatting, Style, Styling

Mahamat Abderraman, G. , Hamat, I. , Tondi, Z. , Lemrabott, A. , Faye, M. , Moustapha, C. , Sabi, K. , Ka, K. , Abdou, N. and Boucar, D. (2017) Hyperuricemia in Patients with Chronic Renal Failure in the General Hospital of National Reference of N’Djamena (Chad). Open Journal of Nephrology, 7, 9-18. doi: 10.4236/ojneph.2017.71002.