Author(s)

Mosselhi A. M. Mohamed^1,2*, Liala M. B. Abu-Alola¹, Ohoud N. A. Al-Zaidi³, Hosam A. H. Saad^1,4

¹Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia.
²Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
³Department of Chemistry, College of Education & Science, Taif University, Taif, Saudi Arabia.
⁴Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11), respectively. The mechanism and the regioselectivity of the studied reactions have been discussed. The biological activity of the products has been evaluated against some fungi and bacteria species. The tested compounds exhibited moderate activity against the bacteria species.

Hydrazonoyl Chlorides, Azines, Fused Heterocycles, Biological Activity

Mohamed, M. , Abu-Alola, L. , Al-Zaidi, O. and Saad, H. (2017) Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity. International Journal of Organic Chemistry, 7, 12-24. doi: 10.4236/ijoc.2017.71002.