This study was executed to identify stress and depression, low religiosity, social injustice and insufficient rehabilitation outcomes as predictors of frequent relapse in drug dependence among drug addicts in Malaysia. 240 samples were randomly selected from the Cure and Care Rehabilitation in the Serendah district to participate in the survey. The questionnaire was designed to collect information about the participants’ demographics including frequency of relapse in drug dependence and the regularity of perceived stress and depression, low religiosity, social injustice and insufficient rehabilitation outcome after being released from detention. The finding shows a combination of stress and depression, insufficient rehabilitation outcome and social injustice increases 2.57 times of the chance of frequent relapse in drug dependence.