Author(s)

Murthy R. Akula¹, Srinivasa R. Marepally¹, Lee T. Collier², W. George Kabalka¹

¹Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee, USA.
²Advion Biosystems, Ithaca, NY, USA.

[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.

Bifunctional Agent, Micro-Reactor, 6-Bromohexnol, Radiofluorination, Appel Reaction

Akula, M. , Marepally, S. , Collier, L. and Kabalka, W. (2016) Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry. International Journal of Organic Chemistry, 6, 177-185. doi: 10.4236/ijoc.2016.63018.