Author(s)

Shigeru Matsushima^1*, Yozo Sato¹, Hidekazu Yamaura¹, Mina Kato¹, Yui Onoda¹, Shinichi Murata¹, Yasuhiro Shimizu², Yasutomi Kinosada³, Hideyuki Nishiofuku⁴, Yoshitaka Inaba¹

¹Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan.
²Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
³Departments of Biomedical Informatics, Gifu University Graduate School of Medicine, Gifu, Japan.
⁴Department of Radiology, Nara Medical University, Nara, Japan.

Purpose: To evaluate posthepatectomy liver failure (PHLF) using gadoxetic acid-enhanced magnetic resonance imaging (MRI) with a measure of relative liver enhancement (RLE) on hepatobiliary phase images, thereby facilitating safe liver resection. Methods: Twenty patients in Child-Pugh class A underwent tumor excision surgery and indocyanine green (ICG) clearance of future remnant liver (FRL) (ICG-Krem) values were >0.05. PHLF was evaluated using the grading system of the International Study Group of Liver Surgery (ISGLS). The RLE value was defined as the signal gain percentage between the precontrast and hepatocellular images. In the whole liver and FRL, theRLE value measured the tumor-free liver parenchyma in RLE images. We examined the correlation between indocyanine green clearance (ICG-K) and MRI-based liver function in the whole liver. Preoperative PHLF evaluation was predicted using remnant hepatocellular uptake index (rHUI), remnant RLE (rRLE), coefficient variation of Rrle [Cv(rRLE)], and ICG-Krem corrected by heterogeneous liver function(HLF-ICG-Krem). Results: HLF-ICG-Krem and rRLE values correlated with INRs after postoperative day five (r = -0.55 and 0.46, p = 0.01 and 0.04, respectively). Furthermore, HLF-ICG-Krem values ≤0.05 detected two patients with higher INRs after postoperative day five. On the other hand, neither rHUI nor Cv(rRLE) was correlated with INRs after postoperative day five (r = 0.28, and -0.03, respectively; p >0.05 for both). HLF-ICG-Krem was significantly lower with PHLF than without PHLF (p = 0.005). Conclusion: HLF-ICG-Krem is useful for evaluating PHLF more correctly.

Posthepatectomy Liver Failure, Heterogeneous Liver Function, Gadoxetic Acid, Relative Liver Enhancement, Indocyanine Green Clearance

Matsushima, S. , Sato, Y. , Yamaura, H. , Kato, M. , Onoda, Y. , Murata, S. , Shimizu, Y. , Kinosada, Y. , Nishiofuku, H. and Inaba, Y. (2016) Preoperative Evaluation of Posthepatectomy Liver Failure Using MRI-Based Liver Function Indices in Child-Pugh Class A Patient. Open Journal of Radiology, 6, 147-156. doi: 10.4236/ojrad.2016.62022.