Author(s)

Mohammad M. Ghanbari^1*, Zahra Roohi¹, Javad Safari²

¹Young Researchers and Elite Club, Sarvestan Branch, Islamic Azad University, Sarvestan, Iran.
²Department of Chemistry, Faculty of Science, University of Kashan, Kashan, Iran.

A convenient, environmentally friendly and mild green synthesis of imidazolidine-2-thiones, hy-dantoin and thiohydantoin derivatives was developed by the one-pot reaction of benzils, urea or thiourea derivatives, and strong base at with grinding. The key advantages are the short reaction times, excellent yields, simple workup, and easy purification in the solvent-free condition. The present method aimed to overcome the limitations and drawbacks of the reported methods such as hard work-up, low yield, hazardous solvent and long reaction time.

Green Synthesis, Imidazolidine-2-Thiones, Hydantoin, Thiohydantoin, Grinding, Solvent-Free

Ghanbari, M. , Roohi, Z. and Safari, J. (2014) One-Pot Synthesis of Imidazolidine-2-Thiones, Hydantoins and Thiohydantoins under Solvent-Free and Grinding Conditions. Open Access Library Journal, 1, 1-5. doi: 10.4236/oalib.1100705.