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FeCl3 Catalyzed One Pot Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles under Solvent-Free Conditions

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DOI: 10.4236/ijoc.2015.52009    5,023 Downloads   5,831 Views Citations

ABSTRACT

An efficient procedure for the preparation of 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation of triethyl orthoformate, amine, and trimethylsilyl azide using inexpensive and environment-friendly FeCl3 as catalyst under solvent-free conditions has been reported. The reaction generates the corresponding 1-substituted tetrazole in excellent yields.

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Darvish, F. and Khazraee, S. (2015) FeCl3 Catalyzed One Pot Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles under Solvent-Free Conditions. International Journal of Organic Chemistry, 5, 75-80. doi: 10.4236/ijoc.2015.52009.

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