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Synthetic Studies of Naphtho[2,3-b]furan Moiety Present in Diverse Bioactive Natural Products

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DOI: 10.4236/ijoc.2015.52008    2,950 Downloads   3,651 Views Citations

ABSTRACT

The preparation of several functionalized furan derivatives and attempts to transform them into a derivative containing 6H-furo[3,4-b]furanone skeleton towards the construction of naphtho[2,3-b] furan are described. Attempted Pummerer reaction of a furan sulfoxide derivative produced four interesting furan derivatives. Base promoted annulation between methyl 2-(phenylsulfinylmethyl)-3-furoate and 2-cyclohexenone proceeded to give dihydro naphtho[2,3-b]furanone derivative in a regiospecific manner.

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Senapati, B. and Mal, D. (2015) Synthetic Studies of Naphtho[2,3-b]furan Moiety Present in Diverse Bioactive Natural Products. International Journal of Organic Chemistry, 5, 63-74. doi: 10.4236/ijoc.2015.52008.

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