Could Ambulatory Blood Pressure Monitoring Be a Routine Investigation for Patients with Mild Cognitive Impairment? - Neuroscience and Medicine

NM > Vol.6 No.2, June 2015

Could Ambulatory Blood Pressure Monitoring Be a Routine Investigation for Patients with Mild Cognitive Impairment? ()

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DOI: 10.4236/nm.2015.62009 3,992 Downloads 4,711 Views Citations

Author(s)

Mohamed Hamdy Ibrahim¹, Tamer Taha Ismail Taha², Laila Adel Mohsen³, Nisrin Moustafa Rizk El-Elsaadouni⁴

Affiliation(s)

¹Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
²Cardiology Department, Faculty of Medicine, Minia University, Minya, Egypt.
³Radiology Department, Faculty of Medicine, Minia University, Minya, Egypt.
⁴Psychiatry Department, Faculty of Medicine, Al-Mansoura University, Mansoura, Egypt.

ABSTRACT

Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including 50male patients with mild cognitive impairment in the age group of 30 - 50 years old. The control group included 30 volunteers with no cognitive impairment and in the same age group (30 - 50 years old) and same gender. Mini-mental estate examination, office and ABP monitoring (ABPM) and brain MRI scans were done for cases and controls. Results: Thirty patients (60%) with MCI revealed a non-dipper blood pressure pattern. Sleeping systolic blood pressure and sleeping systolic load were significantly higher in patients with MCI than in normal volunteers (p = 0.01). MRI brain showed more white matter lesions (WMLs) in patients with MCI than in normal volunteers; however, this didn’t reach significance level (p = 0.056). Conclusion: MCI in normotensive young adult patients could reflect an abnormal circadian blood pressure rhythm. Ambulatory blood pressure monitoring could be an essential investigation in young adult MCI patients.

KEYWORDS

Mild Cognitive Impairment, Ambulatory Blood Pressure Monitoring, White Matter Lesions, Non-Dipper, MMSE

Share and Cite:

Ibrahim, M. , Taha, T. , Mohsen, L. and El-Elsaadouni, N. (2015) Could Ambulatory Blood Pressure Monitoring Be a Routine Investigation for Patients with Mild Cognitive Impairment?. Neuroscience and Medicine, 6, 50-57. doi: 10.4236/nm.2015.62009.

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