Author(s)

Satyanarayana Battu, Vasudev Pottabathini

Department of Chemistry, University College of Science, Osmania University, Hyderabad, India.

Lansoprazole degradation is accelerated in both acidic and basic medium in water. The present investigation deals with the hydrolytic degradation of Lansoprazole. Acidic medium degradation show all known impurities and degradation products whereas basic degradation studies show new impurity which has higher molecular weight than Lansoprazole. New impurity was identified, isolated using mass based auto purification system and characterised by ¹H NMR, ¹³C NMR, HMBC, HSQC, NOE, COSY and HRMS experiments. Isolated impurity was showing molecular weight of 467.10, molecular formula of C₂₃H₁₆F₃N₅OS and its name is 7-(3-Methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)-7H-benzo[4,5]imidazo[2,1-b]benzo[4,5]imidazo[2,1-d][1,3,5]thiadiazine.

Lansoprazole, Hydrolytic Degradation, Isolation, Characterization, Preparative HPLC, ¹H NMR, ¹³C NMR and 2 D NMR

Battu, S. and Pottabathini, V. (2015) Hydrolytic Degradation Study of Lansoprazole, Identification, Isolation and Characterisation of Base Degradation Product. American Journal of Analytical Chemistry, 6, 145-155. doi: 10.4236/ajac.2015.62013.