Author(s)

Marília C. Araujo, Fernanda S. Soares, Merieli M. Ronsani, Luiz G. C. Rocha, Lilian C. Vieira, Luciano A. Silva, Tales de Carvalho, Magnus Benetti, Ricardo A. Pinho

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To investigate the effects of moderate and intense exercise (ME,IE) and lycopene (L) supplementation on oxidative stress biomarkers in patients with CAD. Rehabilitation clinic.Thirty-two male volunteers with CAD (55.65 ? 2.27 years, 77.27 ? 3.95 kg, 171.9 ? 2.80 cm) were divided into four groups; ME-Placebo (n = 7), ME + L (n = 8), IE-Placebo (n = 8) and IE-L (n = 9). Blood samples (12 mL) were collected before supplementation (one cereal bars – 15 mg of syn-thetic lycopene) and exercise (45 min plus 15 min of stretching, 3/wk) and after five weeks of supplementation and 72 h after exercise. Nitrite/nitrate concentrations (NOx), lipoperoxidation (TBARS levels), protein carbonylation (PC) and superoxide dismutase (SOD) and catalase (CAT) activity were assessed in plasma. NOx decreased significantly in the ME-P, IE-P and ME-L groups at 72 h after exercise and increased in the IE-L 72 h after the last exercise session. The IE-L group demonstrated decreased TBARS at 72 h after the last exercise session. The level of PC increased only in EI-P at 72 h after the last exercise session, while only the EI-L group presented a reduction. SOD increased signifi-cantly in both placebo groups 72 h after the last exercise session and decreased in the ME-L group 72 h after in rela-tion to placebo groups. CAT increased in ME-P, IE-P and IE-L groups only at 72 h after the last exercise session. The lycopene supplementation attenuates some markers of oxidative stress associated with IE Lycopene also had dissimilar effects on some markers of oxidative stress in subjects undertaking ME versus IE.

Lycopene, Coronary Artery Disease, Oxidative Stress, Nitric Oxide, Intense Exercise

M. Araujo, F. Soares, M. Ronsani, L. Rocha, L. Vieira, L. Silva, T. Carvalho, M. Benetti and R. Pinho, "Lycopene Supplementation Attenuates Oxidative Stress Parameters in the Plasma of Humans with Cad after Intense Exercise," Food and Nutrition Sciences, Vol. 2 No. 4, 2011, pp. 241-248. doi: 10.4236/fns.2011.24034.