Antioxidant, Antibacterial and Antitumor Activity of Ethanolic Extract of the Psidium guajava Leaves - American Journal of Plant Sciences

AJPS > Vol.5 No.23, November 2014

Antioxidant, Antibacterial and Antitumor Activity of Ethanolic Extract of the Psidium guajava Leaves ()

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DOI: 10.4236/ajps.2014.523365 9,761 Downloads 14,705 Views Citations

Author(s)

Tatiane Vieira Braga^1*, Rosana Gonçalves Rodrigues das Dores², Camila Soncin Ramos², Fernanda Cristina Gontijo Evangelista³, Letícia Márcia da Silva Tinoco⁴, Fernando de Pilla Varotti³, Maria das Graças Carvalho¹, Adriano de Paula Sabino¹

Affiliation(s)

¹Federal University of Minas Gerais, Belo Horizonte, Brazil.
²Federal University of Ouro Preto, Ouro Preto, Brazil.
³Federal University of São João Del Rei, Divinópolis, Brazil.
⁴Pitágoras Faculty, Belo Horizonte, Brazil.

ABSTRACT

Psidium guajava L. has extensive use in folk medicine. The aim of this study was to quantify the levels of phenolic, flavonoids, antioxidant activity, leathality assay and antibacterial and antitumoral activities of the extract of P. guajava. In the dry guava extract there were high levels of phenolics (766.08 ± 14.52 mg/g), flavonoids (118.90 ± 5.47 mg/g) and antioxidant activity (87.65%). The LD50 was 185.15 μg/ml. The MIC value was 250 μg/ml for Streptococcus mutans, Streptococcus mitis and Streptococcus oralis. IC50 of the extract tested in the HeLa, RKO and Wi cell lines was 15.6 ± 0.8 μg/ml, 21.2 ± 1.1 μg/ml and 68.9 ± 1.5 μg/ml, respectively. The results of all analyses allow us to conclude that the dry extract of guava leaves has promising activity to be applied topically in the oral cavity or in the development of antitumor formulation or even be used as a functional food.

KEYWORDS

Guava, Antitumor, Medicinal Plants, Functional Foods

Share and Cite:

Braga, T. , Dores, R. , Ramos, C. , Evangelista, F. , Tinoco, L. , Varotti, F. , Carvalho, M. and Sabino, A. (2014) Antioxidant, Antibacterial and Antitumor Activity of Ethanolic Extract of the Psidium guajava Leaves. American Journal of Plant Sciences, 5, 3492-3500. doi: 10.4236/ajps.2014.523365.

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