Author(s)

Paula Prieto-Oliveira¹, Sérgio Vitorino Cardoso², Florence Zumbaio Mistro³, Sérgio Kignel³, Suzana Cantanhede Orsini Machado de Sousa⁴, Marco Túllio Brazão-Silva⁵

¹Inter-Institutional Grad Program on Bioinformatics, University of São Paulo, São Paulo, Brazil.
²Department of Oral Pathology, School of Dentistry, Federal University of Uberlandia, Uberlandia, Brazil.
³Department of Semiology, School of Dentistry, Fundação Hermínio Ometto, Araras, Brazil.
⁴Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
⁵Department of Oral Diagnosis, School of Dentistry, School of Health Sciences, University of the State of Amazonas, Manaus, Brazil.

Granular cell tumor (GCT) is a rare neoplasm that can occur in any part of the body, but mostly they are located intraorally. Its histogenetic origin remains controversial, but it probably arises from Schwann cells and is generally benign. The tumor is typically asymptomatic and appears as a nodule, with a relatively high predilection for the tongue. This article reports a case of a 72-year-old woman treated at the Center of Oral Diagnosis of the Fundação Hermínio Ometto Dental School. The patient presented with an asymptomatic nodule in the dorsal surface of the tongue for approximately 4 months. The patient was submitted to an excisional biopsy and histopatological examination revealed polyhedral cells with granular aspect. The immunohistochemical staining for S-100 presented strong reactivity, confirming the diagnosis of GCT. Finally, we made a concise discussion about the pathogenesis and fundamental clinico-pathological aspects of GCT making the differential diagnosis.

Granular Cell Tumor, Mouth, Diagnosis

Prieto-Oliveira, P. , Vitorino Cardoso, S. , Zumbaio Mistro, F. , Kignel, S. , Cantanhede Orsini Machado de Sousa, S. and Brazão-Silva, M. (2014) Typical Aspects of the Granular Cell Tumor of the Oral Cavity. International Journal of Otolaryngology and Head & Neck Surgery, 3, 318-322. doi: 10.4236/ijohns.2014.36057.