Author(s)

Sanga Mitra, Smarajit Das, Satyabrata Sahoo, Chandana Sinha, Jayprokas Chakrabarti

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Amongst endonuclease, the homodimeric variety is found in many prokaryotes for processing of the introns out from pre-RNAs. But as the variety and the complexity of introns rise with evolution, do the homodimeric endonuclease adapt to the changes? The correlations between evolving pre-RNAs and adapting homodimeric endonuclease in lower prokaryotes is investigated in this paper. First, we construct and observe the appearance of a long branch in the phylogeny based on homodimeric endonuclease. To appreciate the finer aspects of accelerating evolution near this long branch, we delve deeper into the pre-RNA substrates of the endonuclease. Computational evidence of an as-yet-unreported noncoding RNA gene then emerges from this study. The capabilities of homodimeric endonuclease and the complexities of its pre-RNA substrates appear to evolve in steps together.

Phylogeny; Maximum Likelihood Method; Homodimeric Endonuclease; Noncoding RNA; Intron; Methanogen

Mitra, S. , Das, S. , Sahoo, S. , Sinha, C. and Chakrabarti, J. (2011) Phylogeny derived from homodimeric endonuclease correlates with its pre-RNA substrates. Advances in Bioscience and Biotechnology, 2, 117-122. doi: 10.4236/abb.2011.23018.