Author(s)

Khalid Hussain, Deepak Wadhwa

Department of chemistry, Kurukshetra University, Kurukshetra, India.
Mewat Engineering College (WAKF), Nuh, India.

A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.

Dihydropyridines, Iodobenzene Diacetate, Ultrasonic, Microwave, One-Pot, Formylpyrazoles

Hussain, K. and Wadhwa, D. (2014) Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation. International Journal of Organic Chemistry, 4, 174-181. doi: 10.4236/ijoc.2014.43019.