Buschke-Löwenstein tumor (BLT), or giant condyloma acuminatum, is a rare sexually transmitted disease with a potentially fatal course. The virus responsible for condyloma is human papillomavirus, usually serotype 6 or11. ABLT is always preceded by condyloma acuminatum and may occur at any age after puberty. It is characterized by invasive growth and recurrence after treatment, and malignant transformation is possible. There is no general agreement on the choice of treatment for this tumor. Wide radical excision with plastic reconstruction of skin defects seems to be the best treatment, while adjuvant therapies, such as radiotherapy and immunotherapy, may achieve good results, but their effectiveness is still unclear. We report 3 cases of 32- and 40-year-old males and a 38-year-old female with an approximate 5-year history of a perianal BLT.