Surface temperature and vegetation are the major land cover changes that significantly affect on the thermal environment. In the present study, remote sensing techniques were applied to identify the relationship between anthropogenic activities and the thermal environment in the North Gulf of Suez area. Results have indicated that the urbanization and agricultural expansion have been increased during the last 25 years. Although urban areas increased from 49 km² in 1987 to 57 km² in 2012, the urban heat island-range declined from very high and high, to moderate and low. An expansion in cultivated areas from 3 km² in 1987 to 26 km² in 2012 was responsible for the decline. The results of this study provided valuable information for understanding the local thermal changes that associate rapid urbanization and expansion of cultivated areas. Consequently, this work recommends that proper planning and management regimes for land use and cover changes associated with rapid urbanization will result in positive impacts on the local climate and environment.