Author(s)

Sanjeev Kumar, Reena Mittal, Shweta Chaudhary, Depp Chand Jain

Department of Mathematics, Shri.K.K.JAIN. College, Muzaffarnagar, India.
Department of Neurology, Safdarganj Hospital, New Delhi, India.
Department of Physics, Central Medical Physics Research Laboratory, D.A.V. (P.G.) College, Muzaffarnagar, India.

Our findings show that the value of IgG in serum of Alzheimer’s Disease patients is (17.2059 ± 2.6317) g/l and in controls i.e. (17.6720 ± 3.1457) g/l. Values of IgM in AD patients go down up to 62.5% in comparison to healthy subjects. A sudden change was observed in the levels of IgA of AD patients. It has been put on the value 137.9% high in comparison to healthy subjects. The levels of complement C₃ have also value of lower side and go down up to 52.66% in AD patients. The value of levels of complement C₄ shows no deflection from the control values. On the basis of regression and multiple correlation analysis, we found that the partial correlation coefficients r_GA.M, which has value 0.44815 in AD patients and 0.45555 in controls, do not show any resemblance. The multiple partial correlation r_AM.G has value 0.3082 in AD patients and 0.3912 in controls slightly better correlated in comparison to healthy controls. Multiple RA.MG has strongly correlation in comparison to controls. R_M.AG is also strongly correlated. Regression coefficients and regression equations are basic foundations of correlation measurements and show a specific character of variation. A relation between all the three multiple correlations has been established in the present work and it is given by the following relation R_A.MG > R_M.AG > R_G.AM.

Complements, Immunoglobulins, Alzheimer’s Disease, Regression Coefficients, Multiple Correlation Coefficients

Kumar, S. , Mittal, R. , Chaudhary, S. and Jain, D. (2014) Role of Complements and Immunoglobulins in Alzheimer’s Disease. Open Journal of Applied Sciences, 4, 285-298. doi: 10.4236/ojapps.2014.46028.