Author(s)

Mathieu Wagner, Yohan Contie, Clotilde Ferroud, Gilbert Revial

Conservatoire National des Arts et Métiers, Laboratoire de Transformations Chimiques et Pharmaceutiques, Paris, France.

Six compounds including five proline derivatives have been prepared and tested as chiral organocatalysts for enantioselective aldol reactions and Michael additions. The enantiomeric excesses, which are highly dependent on the molecular structure of catalysts as well as experimental conditions, have reached over 98%.

Aldol Reactions; Michael Additions; Enantioselective; Organocatalysts; Proline Derivatives

Wagner, M. , Contie, Y. , Ferroud, C. and Revial, G. (2014) Enantioselective Aldol Reactions and Michael Additions Using Proline Derivatives as Organocatalysts. International Journal of Organic Chemistry, 4, 55-67. doi: 10.4236/ijoc.2014.41008.