The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial - Open Journal of Gastroenterology

OJGas > Vol.4 No.2, February 2014

The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial ()

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DOI: 10.4236/ojgas.2014.42010 7,651 Downloads 12,433 Views Citations

Author(s)

Patrick P. Basu, Hemanth Hempole, Nitya Krishnaswamy, Niraj J. Shah, Mark M. Aloysius

Affiliation(s)

Columbia University College of Physicians and Surgeons, New York, USA.
James J. Peters VA Medical Center, Mount Sinai School of Medicine, New York, USA.
King’s County Hospital, New York, USA.
North Shore University Hospital at Forest Hills, Forest Hills, USA.

ABSTRACT

Background: Melatonin is a safe and effective treatment for patients with functional pain and gastrointestinal disorders. Objective: To evaluate the efficacy and safety of melatonin for 3 months in patients with functional heartburn. Methods: In the randomized, placebo-controlled pilot study, patients with functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either melatonin 6 mg (n = 20), nortripty line 25 mg (n = 20), or placebo (n = 20) at bedtime for 3 months. Gastroesophageal Reflux Disease-Health-Related Quality of Life (GERD-HRQOL) scores were assessed at baseline and at the end of the study. Results: Melatonin improved GERD-HRQOL scores compared with nortriptyline (P = 0.0015) and placebo (P < 0.0001). Fewer adverse events were reported by patients receiving melatonin compared with those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe and effective treatment for functional heartburn.

KEYWORDS

Melatonin; Functional Heartburn; Nortriptyline; HRQOL

Share and Cite:

Basu, P. , Hempole, H. , Krishnaswamy, N. , Shah, N. and Aloysius, M. (2014) The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial. Open Journal of Gastroenterology, 4, 56-61. doi: 10.4236/ojgas.2014.42010.

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