Author(s)

Dongjun Dai, Lingyan Wang, Limin Xu, Lingling Tang, Xuting Xu, Huadan Ye, Xingyu Zhou, Cheng Chen, Guanghui Pan, Ping Ru, Qingqing Ma, Yi Jiang, Wenjing Yu, Leiting Xu, Meng Ye, Shiwei Duan

Bank of Blood Products, Ningbo No.2 Hospital, Ningbo, China.
The Affiliated Hospital, Ningbo University, Ningbo, China.
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; The Affiliated Hospital, Ningbo University, Ningbo, China.

Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627; IL1B-511: rs16944; IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA.

Rheumatoid Arthritis; Meta-Analysis; Polymorphism; IL1B-511; Dominant Model

Dai, D. , Wang, L. , Xu, L. , Tang, L. , Xu, X. , Ye, H. , Zhou, X. , Chen, C. , Pan, G. , Ru, P. , Ma, Q. , Jiang, Y. , Yu, W. , Xu, L. , Ye, M. and Duan, S. (2014) A comprehensive meta-analysis of the association between three IL1B polymorphisms and rheumatoid arthritis. Advances in Bioscience and Biotechnology, 5, 108-116. doi: 10.4236/abb.2014.52015.