Highly penetration of Distributed Energy Resources (DER) on the grid systems nowadays makes the systems grow dynamically. The system become more complex and the protection system become more complicated. The protection relay should accommodate the system changes according to the system conditions and topologies. As part of developmental aspect of Distributed Artificial Intelligent, Multi Agent System (MAS) is a challenging method for improving the intelligent properties of relay protection. This paper introduces the use of MAS approach on radial distribution system protection dominated with DER using dispersed adaptive rule-based protection supported by distributed database agent. The simulation results confirmed that the proposed algorithm can respond within 15.05 ms.