Incidence of Methicillin Resistant Staphylococcus aureus in Burn Patients Admitted to Burn Unit, Dhaka Medical - Advances in Microbiology

AiM > Vol.3 No.6, October 2013

Incidence of Methicillin Resistant Staphylococcus aureus in Burn Patients Admitted to Burn Unit, Dhaka Medical ()

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DOI: 10.4236/aim.2013.36066 4,863 Downloads 8,990 Views Citations

Author(s)

Md. Shariful Islam, M. Firoz Ahmed, Sabita Rezwana Rahman

Affiliation(s)

.
Department of Microbiology, University of Dhaka, Dhaka, Bangladesh.

ABSTRACT

Staphylococcus aureus infection remains an increasing problem for higher morbidity and mortality in burn patients. We sought to determine the frequency of methicillin-resistant S. aureus (MRSA) in burn wound patients and study their drug resistance genes. Samples were collected (August 2010 to October 2011) from burn unit of Dhaka Medical College Hospital (DMCH), Bangladesh. MRSA was identified by conventional culture based methods. S. aureus was confirmed in 44.44% burn wound samples and 22.5% of the isolates were oxacillin resistant. All the S. aureus isolates were resistant to commonly used drugs like amoxicillin, azactam, erythromycin, azithromycin etc. and were sensitive to imipenem. The isolates were devoid of plasmid and the gene mecA, femA and IS431 were detected in their chromosomal DNA. Computational analysis of mecA gene sequence showed homology to S. aureus “penicillin binding protein 2a” (PBP-2a). The higher association of MRSA is in burn unit of DMCH, Bangladesh is alarming and with inappropriate antibiotic use, and the situation gets even complicated to treat. Therefore, the detection system and control practices for MRSA in DMCH should be improved in the hospital settings.

KEYWORDS

Methicillin Resistant Staphylococcus aureus (MRSA); Multidrug Resistant (MDR); Minimum Inhibitory Concentration (MIC)

Share and Cite:

M. Islam, M. Ahmed and S. Rahman, "Incidence of Methicillin Resistant Staphylococcus aureus in Burn Patients Admitted to Burn Unit, Dhaka Medical," Advances in Microbiology, Vol. 3 No. 6, 2013, pp. 498-503. doi: 10.4236/aim.2013.36066.

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