This paper proposes a new holographic microwave imaging array (HMIA) technique for brain stroke detection. This approach is based on holographic microwave and aperture synthesis imaging techniques. The system is designed for operation at a single frequency of 2.5 GHz. A realistic three dimensional (3D) head model that contains skin, fat, skull, cerebrospinal fluid (CSF), grey matter, white matter and ischemic or hemorrhagic stroke area is developed using MATLAB to demonstrate the proposed HMIA imaging algorithm.A matching solution medium is used between the antennas and the head model. The study is conducted using HMIA computer simulations and 3D head model with-stroke.The simulation results showed that small stroke area (5 mmin diameter) could be successfully detected with the HMIA approach.