Author(s)

Aleksandr Trunov, Olga Obukhova, Olga Gorbenko, Alya Shvayk, Liliya Trunova

Center of Clinical and Experimental medical, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.

In the course of the study there were examined cytokine levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4, IL-6, IL-8, IL-10, IFN-g, G-GSF), and also the levels of progesterone and estradiol in the blood serum with a view to study the pathogenic characteristics of a chronic inflammatory process of the pelvic organs in remission. It was shown that the remission of the disease is characterized by the significant increase in the concentrations of pro-inflammatory cytokines IL-6, IL-8, and also increase of inducers activation of the immune response of the immune response (IL-4 and IFN-g), accompanied by a decrease in the concentration of sex hormones. In women with chronic inflammatory diseases of urogenital sphere in remission tested active immunological process and violation of the synthesis of sex hormones. Revealed changes predispose to the emergence disorders of reproductive health.

Immune Response; Sex Hormones; Chronic Inflammation; Remission; Cytokines

Trunov, A. , Obukhova, O. , Gorbenko, O. , Shvayk, A. and Trunova, L. (2013) Cytokines, estradiol and progesterone in the plasma of women of reproductive age with pelvic inflammatory disease in remission. Advances in Bioscience and Biotechnology, 4, 727-730. doi: 10.4236/abb.2013.46096.