Protein kinase CK2 in the ER stress response - Advances in Biological Chemistry

ABC > Vol.3 No.3, June 2013

Protein kinase CK2 in the ER stress response ()

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DOI: 10.4236/abc.2013.33A001 7,183 Downloads 11,500 Views Citations

Author(s)

Claudia Götz, Mathias Montenarh

Affiliation(s)

Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.

ABSTRACT

The endoplasmic reticulum is the central organelle within a eukaryotic cell where newly synthesized proteins are processed and properly folded. An excess of unfolded or mis-folded proteins induces ER stress signalling pathways. Usually this means a pro-survival strategy for the cell, whereas under extended stress conditions the ER stress signalling pathways have a pro-apoptotic function. CK2 plays a key role in the regulation of the pro-survival as well as the proapoptotic ER stress signalling by directly modulating the activities of members of the ER stress signalling pathways by phosphorylation, regulating the expression of the key factors of the signalling pathways or binding to regulator proteins. The present review will summarize the state of the art in this new emerging field.

KEYWORDS

Protein Kinase CK2; ER Stress; Signalling

Share and Cite:

Götz, C. and Montenarh, M. (2013) Protein kinase CK2 in the ER stress response. Advances in Biological Chemistry, 3, 1-5. doi: 10.4236/abc.2013.33A001.

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