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Development of Film Dosage Forms Containing Miconazole for the Treatment of Oral Candidiasis

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DOI: 10.4236/pp.2013.43047    3,542 Downloads   5,235 Views Citations

ABSTRACT

Film dosage forms (FDs) containing miconazole (MCZ) for the treatment of oral candidiasis were prepared using water-soluble polysaccharides, and the dissolution profiles of MCZ from the FDs were investigated. In addition, the forms were modified by the addition of a surface active agent to accelerate the drug dissolution rate. Circular films incorporating MCZ were obtained using each polysaccharide. Most FDs were easy to handle and resistant to tearing. No diffraction peaks were observed in the X-ray diffractograms of FDs. FDs prepared with sodium alginate or pullulan immediately swelled and disintegrated in aqueous medium, whereas MCZ incorporated in the FD gradually dissolved. A marked acceleration in the MCZ dissolution rate was observed when FD was prepared with polysaccharide containing a surfactant. These results confirmed that modified FDs are useful for treating localized conditions in the oral cavity, such as oral candidiasis, and that FDs can simplify the administration of drugs to patients.

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Y. Murata, T. Isobe, K. Kofuji, N. Nishida and R. Kamaguchi, "Development of Film Dosage Forms Containing Miconazole for the Treatment of Oral Candidiasis," Pharmacology & Pharmacy, Vol. 4 No. 3, 2013, pp. 325-330. doi: 10.4236/pp.2013.43047.

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