ABSTRACT
As elevated triglyceride (TG) to high-density
lipoprotein cholesterol (HDL-C) ratio has been described as predictor for
cardio metabolic disease with insulin resistance (IR) in the background,
the aim was to assess the relationship between this ratio and IR in youth. Oral glucose tolerance test
was performed in 318 Brazilian students (175 girls, 11.2 ± 3.2 years,
BMI_z-score 1.2 ± 1.4 SD). Measurements: BMI, waist circumference (WC), blood
pressure (BP), lipids, insulin and high
sensitivity Creactive protein (hsCRP). Excessive weight and abdominal
obesity were defined using BMI_z-score and WC and IR by Homeostasis model assessment-insulin
resistance (HOMA-IR). TG/HDL-C
median was 2.37. There was an association between TG/ HDL-C and WC, systolic
and diastolic BP, insulin, HOMA-IR, hsCRP, (p < 0.001). Stratified TG/HDL-C
into two groups, based on a cut off point of 2.73 (Group 1: <2.73 and Group
2: ≥2.73). Ad- justing for age, gender, ethnicity TG/HDL-C was an independent
variable predicting IR (PR = 1.44; CI: 1.07 - 1.96; p = 0.018). For every 1 (cm)
in WC increased there was an addition of 0.04 of the value of TG/HDL-C and in
those with TG/HDL-C ≥ 2.73 for every 10 (cm) increase in WC there was an
improve of 4% in the ratio. In conclusion: In youth, the TG/HDL-C ratio could be a useful index for identifying
groups with IR.
Share and Cite:
Oliveira, A. , Oliveira, A. , Oliveira, N. , Oliveira, A. , Almeida, M. , Veneza, L. , Oliveira, A. , Adan, L. and Ladeia, A. (2013) Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?.
Health,
5, 481-485. doi:
10.4236/health.2013.53066.