Obnoxious labels are derogatory terms which speak extensively on the ignorant dispositions of scholars who either rush into faulty conclusions, or have prior decisions to promote class distinction through the uncomplimentary colours they paint of what others hold as divine, spiritual, and transcendental. For such derogatory terms to gain wide audience in a globalized age explain the frame of mind of discordant voices which have been based on arm-chair scholarship. The thrust of this article therefore, is to use Igbo experience to explore the problems of atheism and humanism in a globalized world. The exploratory research will help adopt cultural centred approach in analyzing the dichotomy between the various philosophical view points on God, spirits and man’s religious belief system in Igbo land in particular and Africa in general. It is hoped that the analyses of the challenges posed by atheism and humanism in a globalized world will balance ideas, views, attitudes and behaviour that will reposition Igbo religious beliefs, values and practices in line with the proposed theistic humanism associated with Igbo culture in particular and African culture in general. This will breach the persisted conflict between the sacred and the secular pointing to a dynamic and progressive Igbo culture.