Author(s)

Wagnat W. Wardakhan, Sherif M. Sherif, Rafat M. Mohareb, Amr S. Abouzied

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
National Organization for Drug Control & Research, Cairo, Egypt.

The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.

Acetylhydrazine; Hydrazide-Hydrazone; Thiophene; Thiazole; Pyridine; Coumarin; Antitumor

W. Wardakhan, S. Sherif, R. Mohareb and A. Abouzied, "The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation," International Journal of Organic Chemistry, Vol. 2 No. 4, 2012, pp. 321-331. doi: 10.4236/ijoc.2012.24044.