Author(s)

Anandan Anitha, Shunmugham Loghambal, Lakshmanan Rajendran

Department of Mathematics, The Madura College (Autonomous), Madurai-625011, Tamil Nadu, India.

A mathematical model of an amperometric biosensor with the substrate inhibition for steady-state condition is discussed. The model is based on the system of non-stationary diffusion equation containing a non-linear term related to non-Michaelis–Menten kinetics of the enzymatic reaction. This paper presents the analytical expression of concentrations and current for all values of parameters φ²_s φ²_s α and β . Here the Adomian decomposition method (ADM) is used to find the analytical expressions for substrate, product concentration and current. A comparison of the analytical approximation and numerical simulation is also presented. A good agreement between theoretical predictions and numerical results is observed.

Mathematical Modeling; Non-Linear Equation; Adomian Decomposition Method; AmperometricBiosensor; Reaction-Diffusion System; Substrate Inhibition

A. Anitha, S. Loghambal and L. Rajendran, "Analytical Expressions for Steady-State Concentrations of Substrate and Product in an Amperometric Biosensor with the Substrate Inhibition—The Adomian Decomposition Method," American Journal of Analytical Chemistry, Vol. 3 No. 8, 2012, pp. 495-502. doi: 10.4236/ajac.2012.38066.