Author(s)

Xiaofeng Pang, Hongjuan Zeng, Jialie Liu, Shicheng Wei, Yufeng Zheng

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The nanohydroxyapatites (HAP) and its biological effects have been studied using ultraviolet absorption spectrum, X-ray diffraction (XRD) structure analysis, fluorescent and infrared spectrum of absorption and MTT method. The nanohyd- roxyapatites are prepared and made by using Sol-gel method, in which the parameters of process and reaction are controlled as: PH > 9, Ca/P = 1.67, sintering temperature of 1100?C and sintering time 2 hours. The results of the study show that nanohydroxyapatites can absorb the amino acid molecules, the absorption is better for stronger acidity of amino acids. We also find that the nanohydroxyapatites and complex of nanoHAP+ nanoCrO2 can all restrain the proliferation of cells, but their toxiciteis are all first degree or minor, but the restrained effect of the latter is smaller than that of the former, although they can decrease the relative proliferation rate of cells. The nanohydroxyapatites can also change the molecular structure of human serum albumin.

Nanohydroxyapatite, Cell, Biological Effect, Toxicity, Amino Acids, Sol-Gel

X. Pang, H. Zeng, J. Liu, S. Wei and Y. Zheng, "The Properties of Nanohydroxyapatite Materials and its Biological Effects," Materials Sciences and Applications, Vol. 1 No. 2, 2010, pp. 81-90. doi: 10.4236/msa.2010.12015.