Author(s)

Sulkhan N. Tsagareli, Nino G. Archvadze, Otar Tavdishvili

Biology Department, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
Department of Applied Systems for Pattern Recognition, Institute of Cybernetics, Georgian Technical University, Tbilisi, Georgia.

Unsupervised cluster analysis is proposed for analysis of active avoidance formation in three groups of albino rats: 1) intact; 2) with electrolytic lesions of neocortex over the dorsal hippocampus; and 3) with electrolytic lesions of dorsal hippocampus. The term “behavior vector” has been introduced to assess quantitatively the behavior of rats while learning. The proposed approach enables to assess active avoidance behavior in rats simultaneously by all the test parameters: 1) reaction to the light; 2) reaction to the electric irritation; and 3) inter-trial spontaneous behavior. The animals were grouped by their behavioral resemblance through the learning process. The proposed method facilitates the assessment of learning capacities in animals and paves way for getting additional information concerning correlative relationships between their learning skills and other neuroethological and neurobiological parameters.

Behavior; Learning; Memory; Active Avoidance; Hippocampus; Neocortex; Unsupervised Clustering

S. Tsagareli, N. Archvadze and O. Tavdishvili, "Quantitative Analysis of Formation of Active Avoidance Behavior in the Hippocampus Coagulated and Intact White Albino Rats," Journal of Behavioral and Brain Science, Vol. 2 No. 1, 2012, pp. 10-17. doi: 10.4236/jbbs.2012.21002.