Biography

Prof. Richard C. Schwartz

Department of Microbiology and Molecular Genetics

Michigan State University, USA


Email: schwart9@msu.edu


Qualifications


1980 Ph.D., Massachusetts Institute of Technology, Biochemistry

1974 B.S., University of California at Irvine, Biological Sciences


Publications (selected)

  1. Zhao, Y., Y. S. Tan, M. D. Aupperlee, I. M. Langohr, R. C. Schwartz, and S. Z. Haslam. 2013. Pubertal high fat diet: effects on mammary cancer development. Breast Cancer Res. 15: R100. [Epub ahead of print]
  2. Aupperlee, M. D., J. R. Leipprandt, J. M. Bennett, R. C. Schwartz, and S. Z. Haslam. 2013. Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res. 15: R44. [Epub ahead of print].
  3. Motyl, K. J., M. Raetz, S. Tekalur, R. C. Schwartz, and L. R. McCabe. 2011. CCAAT/enhancer binding protein beta-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorption. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300: R1250-60.
  4. Haslam, S. Z. and Schwartz, R. C. Is there a link between a high-fat diet during puberty and breast cancer risk? 2011. Women’s Health 7: 1-3.
  5. Hunter, C., T. B. Kadakia, D. Cooper, M. Perretti, R. C. Schwartz, and S. B. Brown. 2010. Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands. ScientificWorldJournal 10: 1580-1596.
  6. Gao, H. and R. C. Schwartz. 2009. C/EBPζ (CHOP/gadd153) is a negative regulator of LPS-induced IL-6 expression in B cells. Mol. Immunol. 47: 390-397.
  7. Santos, S. J., M. D. Aupperlee, J. Xie, S. Durairaj, R. Miksicek, S. E. Conrad, J. R. Leipprandt, Y. S. Tan, R. C. Schwartz, and S. Z. Haslam. 2009. Progesterone receptor A-regulated gene expression in mammary organoid cultures. J. Steroid Biochem. and Molec. Biol. 5: 161-172.
  8. Motyl, K. J., S. Botolin, R. Irwin, D. M. Appeldorn, T. Kadakia, A. Amalfitano, R. C. Schwartz, and L. R. McCabe. 2009. Bone inflammation and altered gene expression with type I diabetes early onset. J. Cell. Physiol. 218: 575–583.
  9. Aupperlee M. D., A. A. Drolet, S. Durairaj, W. Wang, R. C. Schwartz, and S. Z. Haslam. 2009. Strain-specific differences in the mechanisms of progesterone regulation of murine mammary development. Endocrinol. 150:1485-1494.
  10. Spooner C. J., T. Sebastian, J. D. Shuman, S. Durairaj, X. Guo, P. F. Johnson, and R. C. Schwartz. 2007. C/EBPb Serine 64, a Phosphoacceptor Site, has a Critical Role in LPS-Induced IL-6 and MCP-1 Transcription. Cytokine 37:119-127.
  11. 11. Spooner, C. J., X. Guo, P. F. Johnson, and R. C. Schwartz. 2007. Differential roles of C/EBPb regulatory domains in specifying MCP-1 and IL-6 transcription. Mol. Immunol. 44:1384-1392.
  12. Iyer, V. V., T. B. Kadakia, L. R. McCabe, and R. C. Schwartz. 2004. CCAAT/enhancer-binding protein-b has a role in osteoblast proliferation and differentiation. Exp. Cell Res. 295: 128-137.
  13. Laakko, T., R. C. Schwartz, and P. J. Fraker. 2002. IL-7-mediated protection of pro and pre-B cells from the adverse effects of corticosterone. Cell. Immunol. 220: 39-50.
  14. Gao, H., S. Parkin, P. F. Johnson, and R. C. Schwartz. 2002. C/EBPg has a stimulatory role on the IL-6 and IL-8 promoters. J. Biol. Chem. 277: 38827-38837.
  15. Parkin, S. E., M. Baer, T. D. Copeland, R. C. Schwartz, and P. F. Johnson. 2002. Regulation of C/EBP activator proteins by heterodimerization with C/EBPg (Ig/EBP). J. Biol. Chem. 277: 23563-23572.
  16. Wang, S.-S., R. C. Schwartz, and J. J. Pestka. 2001. Superinduction of TNF- and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. Toxicology 161: 139-149.
  17. Hu, H.-M., Q. Tian, M. Baer, C. J. Spooner, S. C. Williams, P. F. Johnson, and R. C. Schwartz. 2000. The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. J. Biol. Chem. 275: 16373-16381.
  18. 18. Baer, M., A. Dillner, R. C. Schwartz, C. Sedon, S. Nedospasov, and P. F. Johnson. 1998. Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kB p50. Mol. Cell. Biol. 18: 5678-5689.
  19. Williams, S. C., Y. Du, R. C. Schwartz, S. R. Weiler, M. Ortiz, J. R. Keller, and P. F. Johnson. 1998. C/EBPe is a myeloid-specific activator of cytokine, chemokine and macrophage-colony stimulating factor receptor genes. J. Biol. Chem. 273: 13493‑13501.
  20. Baer, M., S. C. Williams, A. Dillner, R. C. Schwartz, and P. F. Johnson. 1998. Autocrine signals control CCAAT/Enhancer Binding Protein b expression, localization, and activity in macrophages. Blood 92: 4353-4365.
  21. Hu, H.-M., M. Baer, S. C. Williams, P. F. Johnson, and R. C. Schwartz. 1998. Redundancy of CEBPa, -b, and -d in supporting the lipopolysaccharide-induced transcription of interleukin 6 and monocyte chemoattractant protein 1. J. Immunol. 160: 2334-2342.
  22. Weichert, T. R., and R. C. Schwartz. 1997. Induction of murine CD5 expression by v-H-ras. Immunology 90: 30-37.
  23. Weichert, T. R., and R. C. Schwartz. 1995. Cloning of the murine CD5 promoter and its tissue-specific regulation. J. Immunol. 154: 4603-4612.
  24. Bretz, J. D., S. C. Williams, M. Baer, P. F. Johnson, and R. C. Schwartz. 1994. C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line. Proc. Natl. Acad. Sci. USA 91: 7306-7310.
  25. Chen, S.-C., D. Redenius, J. C. Young, and R. C. Schwartz. 1993. Synergy of IL-7 and v-Ha-ras in the in vitro neoplastic progression of murine pre-B cells. Oncogene 8: 2119-2125.
  26. Bretz, J. D., S.-C. Chen, D. Redenius, H.-L. Chang, W. J. Esselman and R. C. Schwartz. 1992. Lineage switch macrophages can present antigen. Dev. Immunol. 2: 249-261.
  27. Muirhead, M., R. C. Schwartz and T. J. Waldschmidt. 1992. Use of a modified transwell culture to quantitate the contribution of non-IL-7 substances to growth of an IL-7 dependent pre-B cell clone. Lymphokine Cytokine Res. 11: 167-173.
  28. Bretz, J. D., S.-C. Chen, and R. C. Schwartz. 1992. Antigen presentation after macrophage lineage switch of CD5 pre-B cells. Ann. N.Y. Acad. Sci. 651: 155-156.
  29. Chen, S.-C., D. Redenius, and R. C. Schwartz. 1991. Tumorigenesis of a v-Ha-ras-expressing pre-B cell line selects for c-myc activation. Biochem. Biophys. Res. Comm. 178: 1343-1350.
  30. Muirhead, M., R. Davis, R. C. Schwartz, T. J. Waldschmidt, L. Ackermann, G. Palumbo, and R. G. Smith. 1990. Several types of adherent cells elaborate a dialyzable lymphopoietic cofactor (Abelson growth promoter). Intl. J. Cell Cloning 8: 392-408.
  31. Schwartz, R. C., and O. N. Witte. 1988. A recombinant murine retrovirus expressing v-rel is cytopathic. Virol. 165: 182-190.
  32. Schwartz, R. C., and O. N. Witte. 1988. The role of multiple oncogenes in hematopoietic neoplasia. Mutation Research 195: 245-253.
  33. Schwartz, R. C., L. W. Stanton, K. B. Marcu, and O. N. Witte. 1986. An in vitro model for tumor progression in murine lymphoid cells. Curr. Topics Micro. Immunol. 132: 75-80.
  34. Schwartz, R. C., L. W. Stanton, S. C. Riley, K. B. Marcu, and O. N. Witte. 1986. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol. Cell. Biol. 6: 3221-3231.
  35. Phizicky, E. M., R. C. Schwartz, and J. Abelson. 1986. S. cerevisiae tRNA ligase: purification of the protein and isolation of the structural gene. J. Biol. Chem. 261: 2978-2986.
  36. Schwartz, R. C., C. L. Greer, P. Gegenheimer, and J. Abelson. 1983. Enzymatic mechanism of an RNA ligase from wheat germ. J. Biol. Chem. 258: 8374-8383.
  37. Schwartz, R. C., G. E. Sonenshein, A. Bothwell, and M. L. Gefter. 1981. Multiple expression of Ig l-chain encoding RNA species in murine plasmacytoma cells. J. Immunol. 126: 2104-2108.
  38. Ponte, P. A., M. Siekevitz, R. C. Schwartz, M. L. Gefter, and G. E. Sonenshein. 1981. Transcription of immunoglobulin heavy-chain sequences from the excluded allele. Nature 291: 594-596.
  39. Bothwell, A.L.M., M. Paskind, R. C. Schwartz, G. E. Sonenshein, M. L. Gefter, and D. Baltimore. 1981. Dual expression of l genes in the MOPC-315 plasmacytoma. Nature 290: 65-67.

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