Prof. Richard C. Schwartz
Department of Microbiology and Molecular Genetics
Michigan State University, USA
Email: schwart9@msu.edu
Qualifications
1980 Ph.D., Massachusetts
Institute of Technology, Biochemistry
1974 B.S., University
of California at Irvine, Biological Sciences
Publications (selected)
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Zhao, Y., Y. S. Tan, M. D. Aupperlee, I. M. Langohr, R. C.
Schwartz, and S. Z. Haslam. 2013. Pubertal
high fat diet: effects on mammary cancer development. Breast Cancer Res. 15: R100. [Epub ahead of print]
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Aupperlee,
M. D., J. R. Leipprandt, J. M. Bennett, R. C. Schwartz, and S. Z. Haslam. 2013. Amphiregulin mediates
progesterone-induced mammary ductal development during puberty. Breast Cancer
Res. 15: R44. [Epub ahead of
print].
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Motyl,
K. J., M. Raetz, S. Tekalur, R. C. Schwartz, and L. R. McCabe. 2011.
CCAAT/enhancer binding protein beta-deficiency enhances type 1 diabetic bone
phenotype by increasing marrow adiposity and bone resorption. Am. J. Physiol. Regul.
Integr. Comp. Physiol. 300:
R1250-60.
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Haslam,
S. Z. and Schwartz, R. C. Is there a link between a high-fat diet during
puberty and breast cancer risk? 2011. Women’s Health 7: 1-3.
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Hunter,
C., T. B. Kadakia, D. Cooper, M. Perretti, R. C. Schwartz, and S. B. Brown.
2010. Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in
response to TLR/IL-1R ligands. ScientificWorldJournal 10: 1580-1596.
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Gao, H. and R. C. Schwartz. 2009.
C/EBPζ (CHOP/gadd153) is a negative regulator of LPS-induced IL-6 expression in
B cells. Mol. Immunol. 47: 390-397.
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Santos,
S. J., M. D. Aupperlee, J. Xie, S. Durairaj, R. Miksicek, S. E. Conrad, J. R. Leipprandt,
Y. S. Tan, R. C. Schwartz, and S. Z. Haslam. 2009. Progesterone receptor A-regulated gene expression in mammary organoid
cultures. J. Steroid Biochem. and Molec. Biol. 5: 161-172.
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Motyl, K. J., S. Botolin, R.
Irwin, D. M. Appeldorn, T. Kadakia, A. Amalfitano, R. C. Schwartz, and L. R.
McCabe. 2009. Bone inflammation and altered gene expression with type I
diabetes early onset. J. Cell. Physiol. 218:
575–583.
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Aupperlee M. D., A. A. Drolet, S.
Durairaj, W. Wang, R. C. Schwartz, and S. Z. Haslam. 2009. Strain-specific
differences in the mechanisms of progesterone regulation of murine mammary
development. Endocrinol. 150:1485-1494.
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Spooner C. J., T. Sebastian, J.
D. Shuman, S. Durairaj, X. Guo, P. F. Johnson, and R. C. Schwartz. 2007. C/EBPb Serine 64, a Phosphoacceptor Site, has a Critical Role in LPS-Induced IL-6 and
MCP-1 Transcription. Cytokine 37:119-127.
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11. Spooner,
C. J., X. Guo, P. F. Johnson, and R. C. Schwartz. 2007. Differential roles of
C/EBPb regulatory domains in specifying MCP-1
and IL-6 transcription. Mol. Immunol. 44:1384-1392.
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Iyer,
V. V., T. B. Kadakia, L. R. McCabe, and R. C. Schwartz. 2004.
CCAAT/enhancer-binding protein-b has a role in osteoblast proliferation and differentiation. Exp. Cell Res. 295:
128-137.
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Laakko,
T., R. C. Schwartz, and P. J. Fraker. 2002. IL-7-mediated protection of pro and
pre-B cells from the adverse effects of corticosterone. Cell. Immunol. 220:
39-50.
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Gao,
H., S. Parkin, P. F. Johnson, and R. C. Schwartz. 2002. C/EBPg has a stimulatory role on the IL-6 and IL-8 promoters. J. Biol. Chem. 277:
38827-38837.
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Parkin,
S. E., M. Baer, T. D. Copeland, R. C. Schwartz, and P. F. Johnson. 2002.
Regulation of C/EBP activator proteins by heterodimerization with C/EBPg (Ig/EBP). J. Biol. Chem. 277: 23563-23572.
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Wang,
S.-S., R. C. Schwartz, and J. J. Pestka. 2001. Superinduction of TNF- and IL-6
in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization.
Toxicology 161: 139-149.
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Hu,
H.-M., Q. Tian, M. Baer, C. J. Spooner, S. C. Williams, P. F. Johnson, and R.
C. Schwartz. 2000. The C/EBP bZIP domain can mediate lipopolysaccharide
induction of the proinflammatory cytokines interleukin-6 and monocyte
chemoattractant protein-1. J. Biol. Chem. 275: 16373-16381.
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18. Baer,
M., A. Dillner, R. C. Schwartz, C. Sedon, S. Nedospasov, and P. F.
Johnson. 1998. Tumor necrosis factor alpha transcription in
macrophages is attenuated by an autocrine factor that preferentially induces
NF-kB p50. Mol. Cell. Biol. 18: 5678-5689.
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Williams,
S. C., Y. Du, R. C. Schwartz, S. R. Weiler, M. Ortiz, J. R. Keller, and P. F.
Johnson. 1998. C/EBPe is a myeloid-specific activator of
cytokine, chemokine and macrophage-colony stimulating factor receptor genes. J.
Biol. Chem. 273: 13493‑13501.
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Baer,
M., S. C. Williams, A. Dillner, R. C. Schwartz, and P. F. Johnson. 1998. Autocrine signals control CCAAT/Enhancer Binding Protein b expression, localization, and activity in macrophages. Blood 92: 4353-4365.
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Hu,
H.-M., M. Baer, S. C. Williams, P. F. Johnson, and R. C. Schwartz. 1998. Redundancy of CEBPa, -b,
and -d in supporting the
lipopolysaccharide-induced transcription of interleukin 6 and monocyte
chemoattractant protein 1. J. Immunol. 160: 2334-2342.
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Weichert,
T. R., and R. C. Schwartz. 1997. Induction of murine CD5 expression by
v-H-ras. Immunology 90: 30-37.
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Weichert,
T. R., and R. C. Schwartz. 1995. Cloning of the murine CD5 promoter and its
tissue-specific regulation. J.
Immunol. 154: 4603-4612.
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Bretz,
J. D., S. C. Williams, M. Baer, P. F. Johnson, and R. C. Schwartz. 1994. C/EBP-related protein 2 confers lipopolysaccharide-inducible expression
of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell
line. Proc. Natl. Acad. Sci. USA 91: 7306-7310.
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Chen,
S.-C., D. Redenius, J. C. Young, and R. C. Schwartz. 1993. Synergy of IL-7 and v-Ha-ras in the in vitro neoplastic
progression of murine pre-B cells. Oncogene 8: 2119-2125.
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Bretz,
J. D., S.-C. Chen, D. Redenius, H.-L. Chang, W. J. Esselman and R. C. Schwartz.
1992. Lineage switch macrophages can present antigen. Dev. Immunol. 2: 249-261.
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Muirhead,
M., R. C. Schwartz and T. J. Waldschmidt. 1992. Use of a modified transwell
culture to quantitate the contribution of non-IL-7 substances to growth of an
IL-7 dependent pre-B cell clone. Lymphokine Cytokine Res. 11: 167-173.
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Bretz,
J. D., S.-C. Chen, and R. C. Schwartz. 1992. Antigen presentation after macrophage lineage switch of CD5 pre-B
cells. Ann. N.Y. Acad. Sci. 651: 155-156.
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Chen,
S.-C., D. Redenius, and R. C. Schwartz. 1991. Tumorigenesis of a v-Ha-ras-expressing pre-B cell line selects
for c-myc activation. Biochem.
Biophys. Res. Comm. 178: 1343-1350.
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Muirhead,
M., R. Davis, R. C. Schwartz, T. J. Waldschmidt, L. Ackermann, G. Palumbo, and R. G. Smith. 1990.
Several types of adherent cells elaborate a dialyzable lymphopoietic cofactor
(Abelson growth promoter). Intl. J. Cell
Cloning 8: 392-408.
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Schwartz,
R. C., and O. N. Witte. 1988. A recombinant murine retrovirus expressing v-rel
is cytopathic. Virol. 165: 182-190.
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Schwartz,
R. C., and O. N. Witte. 1988. The role of multiple oncogenes in hematopoietic
neoplasia. Mutation Research 195: 245-253.
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Schwartz,
R. C., L. W. Stanton, K. B. Marcu, and O. N. Witte. 1986. An in
vitro model for tumor progression in murine lymphoid cells. Curr. Topics
Micro. Immunol. 132: 75-80.
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Schwartz,
R. C., L. W. Stanton, S. C. Riley, K. B. Marcu, and O. N. Witte. 1986. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol. Cell. Biol. 6: 3221-3231.
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Phizicky,
E. M., R. C. Schwartz, and J. Abelson. 1986. S. cerevisiae tRNA ligase: purification of the protein and isolation of the structural gene. J.
Biol. Chem. 261: 2978-2986.
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Schwartz,
R. C., C. L. Greer, P. Gegenheimer, and J. Abelson. 1983. Enzymatic mechanism of an RNA ligase
from wheat germ. J. Biol. Chem. 258: 8374-8383.
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Schwartz,
R. C., G. E. Sonenshein, A. Bothwell, and M. L. Gefter. 1981. Multiple expression of Ig l-chain
encoding RNA species in murine plasmacytoma cells. J. Immunol. 126: 2104-2108.
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Ponte,
P. A., M. Siekevitz, R. C. Schwartz, M. L. Gefter, and G. E. Sonenshein. 1981. Transcription of immunoglobulin
heavy-chain sequences from the excluded allele. Nature 291: 594-596.
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Bothwell,
A.L.M., M. Paskind, R. C. Schwartz, G. E. Sonenshein, M. L. Gefter, and D.
Baltimore. 1981. Dual expression of l genes in the MOPC-315
plasmacytoma. Nature 290: 65-67.
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