Dr. Jessy
John Alexander
Department
of Medicine,
The
University of Chicago, USA
Associate
Professor
Email: jalexand@medicine.bsd.uchicago.edu
Qualifications
1990 Ph.D., Biochemistry, University of Hyderabad, India
1982 M.Sc., Zoology, Osmania University, India
1980 B.Sc., Biology, Physics, Chemistry, Osmania University, India
Publications (Selected)
Books
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Chang A., P.
Kadambi and J. J. Alexander. 2006. Membranoproliferative
glomerulonephritis. Florian Lang (ed): Encyclopedic Reference of Molecular
Mechanisms of Disease. Springer Verlag.
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Alexander,
J. J., and
R. J. Quigg. 2007. Systemic lupus erythematosus and the brain: What mice are
telling us. Neurochem Int. 50: 5.
-
Alexander,
J. J., and
R. J. Quigg. 2007. The simple design of complement factor H: Looks can be
deceiving. Mol. Immunol. 44:123 (invited).
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Smith
R.J., J. J. Alexander, P. N. Barlow,
M. Botto, T. L. Cassavant, H. T. Cook, S. R. de Cordoba, G. S. Hageman, T. S. Jokiranta,
W. J. Kimberling, J. D. Lambris, L. D. Lanning, V. Levidiotis, C. Licht, H. U.
Lutz, S. Meri, M. C. Pickering, R. J. Quigg, A. L. Rops, D. J. Salant, S. Sethi,
J. M. Thurman, H. F. Tully, S. P. Tully, J. van der Vlag, P. D. Walker, R. Wurzner
and P. F. Zipfel; Dense Deposit Disease Focus Group.H 2007. New approaches to the treatment of
dense deposit disease. J Am Soc Nephrol. 18(9): 2447-56.
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Alexander, J .J., A. J. Anderson, S. R. Barnum, B. Stevens and A. J. Tenner. 2008. The Complement
Cascade: Yin-yang in Neuroinflammation: Neuro-protection and -degeneration. J.
Neurochemistry, Dec;107(5): 1169-87.
Journals
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Cunningham, P. N.,
V. M. Holers, J. J. Alexander, J. M.
Guthridge, M. C. Carroll, and R. J. Quigg. 2000. Complement is activated in
kidney by endotoxin but does not cause the ensuing acute renal failure. Kidney
Int. 58: 1580.
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Schiller, B., P. N.
Cunningham, J. J. Alexander, L. Bao,
V. M. Holers, and R. J. Quigg. 2001. Expression of a soluble complement
inhibitor protects transgenic mice from antibody-induced acute renal failure. J
Am Soc Nephrol. 12: 71.
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Park, P., M. Haas,
P. N. Cunningham, J. J. Alexander,
L. Bao, J. M. Guthridge, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2001.
Inhibiting the complement system does not reduce injury in renal ischemia reperfusion.
J Am Soc Nephrol. 12: 1383.
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Alexander,
J. J., B.
K. Hack, P. N. Cunningham, and R. J. Quigg. 2001. A protein with
characteristics of factor H is present on rodent platelets and functions as the
immune adherence receptor. J Biol. Chem. 276: 32129.
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Park, P., M. Haas,
P. N. Cunningham, J. J. Alexander,
L. Bao, J. M. Guthridge, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2001.
Inhibiting the complement system does not reduce injury in renal ischemia
reperfusion. J Am Soc Nephrol. 12: 1383.
-
Park, P., M. Haas,
P. N. Cunningham, L. Bao, J. J.
Alexander, and R. J. Quigg. 2002. Injury in renal ischemia-reperfusion is
independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol
282: F352-F357.
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Bao, L., M. Haas,
S. A. Boackle, D. M. Kraus, P. N. Cunningham, P. Park, J. J. Alexander, R. K. Anderson, K. Culhane, V. M. Holers, and R.
J. Quigg. 2002. Transgenic expression of a soluble complement inhibitor
protects against renal disease and promotes survival in MRL/lpr mice. J Immunol.
168: 3601.
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Ren, G., B. K.
Hack, A. W. Minto, P. N. Cunningham, J.
J. Alexander, M. Haas, and R. J. Quigg. 2002. A complement-dependent model
of thrombotic thrombocytopenic purpura induced by antibodies reactive with
endothelial cells. Clin. Immunol. 103: 43.
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Ren, G.,
M. Doshi, B. K. Hack, J. J. Alexander,
and R. J. Quigg. 2002. Isolation and characterization of a novel rat factor
H-related protein that is up-regulated in glomeruli under complement attack. J
Biol. Chem. 277: 48351.
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Alexander, J. J., A. K.
Saxena, L. Bao, A. Jacob, M. Haas, and R. J. Quigg. 2002. Prominent renal
expression of a murine leukemia retrovirus in experimental systemic lupus
erythematosus. J Am Soc Nephrol. 13: 2869.
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Wyss-Coray,
T., F. Yan, A. H. Lin, J. D. Lambris, J.
J. Alexander, R. J. Quigg, and E. Masliah. 2002. Prominent
neurodegeneration and increased plaque formation in complement-inhibited
Alzheimer's mice. Proc. Natl. Acad. Sci. U. S. A 99: 10837.
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Ren, G., M. Doshi,
B. K. Hack, J. J. Alexander, and R.
J. Quigg. 2003. Rat glomerular epithelial cells produce and bear factor H on
their surface that is up-regulated under complement attack. Kidney Int. 64: 914.
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Alexander,
J. J., L.
Bao, A. Jacob, D. M. Kraus, V. M. Holers, and R. J. Quigg. 2003. Administration
of the soluble complement inhibitor, Crry-Ig, reduces inflammation and
aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta 1639: 169.
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Alexander,
J. J., C.
Zwingmann, and R. Quigg. 2005. MRL/lpr mice have alterations in brain
metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int. 47:143.
-
Alexander,
J. J., M.
C. Pickering, M. Haas, I. Osawe, and R. J. Quigg. 2005. Complement factor h
limits immune complex deposition and prevents inflammation and scarring in
glomeruli of mice with chronic serum sickness. J Am Soc Nephrol. 16: 52
-
Alexander,
J. J., A.
Jacob, L. Bao, R. L. Macdonald, and R. J. Quigg. 2005. Complement-dependent
apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol.
175: 8312.
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Alexander,
J. J., O.
G. Aneziokoro, A. Chang, B. K. Hack, A. Markaryan, A. Jacob, R. Luo, M.
Thirman, M. Haas, and R. J. Quigg. 2006. Distinct and separable roles of the
complement system in factor H-deficient bone marrow chimeric mice with immune
complex disease. J Am Soc Nephrol. 17: 1354.
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Wang, Y., J. Zhou,
A. W. Minto, B. K. Hack, J. J. Alexander,
M. Haas, Y. C. Li, C. W. Heilig, and R. J. Quigg. 2006. Altered vitamin D
metabolism in type II diabetic mouse glomeruli may provide protection from
diabetic nephropathy. Kidney Int. 70: 882.
-
Alexander,
J. J., Y.
Wang, A. Chang, M. Karmegam, A. Jacob, M. Haas, A. Minto and R. J.Quigg. 2007. Rodent
factor H functions as a counterpart of human CR1 in renal immune complex
processing. J Am Soc Nephrol. 18(4): 1157-66.
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Alexander,
J. J., A.
Jacob, P. Vezina, H. Sekine, G. S. Gilkeson, and R.
J. Quigg. 2007. Absence of functional alternative complement pathway alleviates
lupus cerebritis. European J. Immunology. 37(6): 1691-701.
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Alexander,
J. J., C. Zwingmann, A. Jacob and R. J. Quigg. 2007.
Alteration in kidney glucose and amino acids are implicated in renal pathology
in MRL/lpr mice. Biochim Biophys Acta
(Molecular Basis of Disease). 1772(10): 1143-9.
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Jacob, A., L. Hensley, B. Safratowich, R. J. Quigg, and J. J. Alexander. 2007. The role of the complement cascade in endotoxin-induced
septic encephalopathy. Lab Invest. 87(12): 1186-94.
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Alexander,
J. J., A.
Jacob, P. N. Cunningham, L. Hensley, and R. J. Quigg. 2008. TNF
is a key mediator of Septic Encephalopathy acting through its receptor, TNF
Receptor-1. Neurochem Int. 52(3): 447-56.
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Jacob, A., Brorson, J., Bao, L., R. J. Quigg, and J. J. Alexander. 2010. C3aR inhibition reduces neurodegeneration
in experimental lupus. Lupus 19(1): 73-82.
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Jacob, A., Hack, B., Chiang, E., Garcia,
J.G.N., R. J. Quigg, and J. J.
Alexander. 2010. C5a alters
blood-brain barrier integrity in experimental lupus. FASEB J. 24(6): 1682-8.
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Jacob A, Hack B,
Bai T, Brorson JR, Quigg RJ, Alexander
JJ.2010. Inhibition of C5a receptor alleviates
experimental CNS lupus. J Neuroimmunol. 221(1-2): 46-52.
-
Alexander
JJ,
Hack BK, Jacob A, Chang A, Haas M, Finberg RW, Quigg RJ. 2010. Abnormal immune complex processing
and spontaneous glomerulonephritis in complement factor H-deficient mice with
human complement receptor 1 on erythrocytes. J
Immunol. 185(6): 3759-67.
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Jacob A, Hack BK,
Chen P, Quigg RJ, Alexander JJ. 2011. C5a/CD88
signaling alters blood-brain barrier integrity in lupus through nuclear
factor-κB. J Neurochem. 119(5): 1041-51.