Organic Chemistry

Instituto Oswaldo Cruz-FIOCRUZ, Brazil

Associate Reseracher

Email: floriano@ioc.fiocruz.br

Research fields:

Bioorganic & Medicinal Chemistry

Structural Bioinformatics & Molecular Modeling

Qualifications

2005 Ph.D., Org. Chem., Federal University of Rio de Janeiro, Brazil

2001 B.Sc., Industrial Pharm., Federal Fluminense University, Brazil

Publications (Selected)

1. Neves, Amanda P. ; Pereira, Michelle X.G. ; Peterson, Erica J. ; Kipping, Ralph ; Vargas, Maria D. ; Silva-Jr, Floriano P. ; Carneiro, J. Walkimar M. ; Farrell, Nicholas P. . Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. Journal of Inorganic Biochemistry, v. 119, p. 54-64, 2013.
2. Silveira, Lucas B. ; Marchi-Salvador, Daniela P. ; Santos-Filho, Norival A. ; Silva-Jr, Floriano P. ; Marcussi, Silvana ; Fuly, André L. ; Nomizo, Auro ; da Silva, Saulo L. ; Stábeli, Rodrigo G. ; Arantes, Eliane C. ; Soares, Andreimar M. . Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom. Journal of Pharmaceutical and Biomedical Analysis (Print), v. 73, p. 35-43, 2013.
3. De Oliveira, Ramatis Birnfeld ; Senger, Mario Roberto ; Vasques, Laura Milan ; Gasparotto, Juciano ; Dos Santos, João Paulo Almeida ; De Bittencourt Pasquali, Matheus Augusto ; Moreira, José Claudio Fonseca ; Silva-Jr, Floriano P.; Gelain, Daniel Pens . Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. International Journal for Parasitology, v. 43, p. 371-379, 2013.
4. Trevizano, Larissa Mattos ; Ventorim, Rafaela Zandonade ; Rezende, Sebastião Tavares de ; Silva-Jr, Floriano P.; Guimarães, Valéria Monteze . Thermostability improvement of Orpinomyces sp. xylanase by directed evolution. Journal of Molecular Catalysis. B, Enzymatic (Print), v. 81, p. 12-18, 2012.
5. Senger, M. R. ; Gomes, L. C. A. ; Ferreira, S. B. ; Kaiser, Carlos Roland ; Ferreira, V. F. ; Silva-Jr, Floriano P. Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity. ChemBioChem (Print), v. 13, p. 1584-1593, 2012.
6. Beghini, D. G. ; Ferreira, A. T. S. ; Almeida, V. C. ; Caminha, M. A. ; Silva-Jr, Floriano P.; Perales, J. ; Menna-Barreto, R. F. S. . New insights in Trypanosoma cruzi proteomic map: further post-translational modifications and potential drug targets in Y strain epimastigotes. Journal of Integrated OMICS, v. 2, p. .-., 2012.
7. Teixeira, Sabrina S. ; Silveira, Lucas B. ; da Silva, Franco M. N. ; Marchi-Salvador, Daniela P. ; Silva-Jr, Floriano P.; Izidoro, Luiz Fernando M. ; Fuly, André L. ; Juliano, Maria A. ; dos Santos, Camila R. ; Murakami, Mário T. ; Sampaio, Suely V. ; da Silva, Saulo L. ; Soares, Andreimar M. . Molecular characterization of an acidic phospholipase A2 from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region. Archives of Toxicology, v. 85, p. 1219-1233, 2011.
8. Ferreira, Sabrina B. ; Sodero, Ana C. R. ; Cardoso, Mariana F. C. ; Lima, Emerson S. ; Kaiser, Carlos R. ; Silva-Jr, Floriano P.; Ferreira, Vitor F. . Synthesis, Biological Activity, and Molecular Modeling Studies of 1 H -1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases Inhibitors . Journal of Medicinal Chemistry, v. 53, p. 2364-2375, 2010.
9. Romero, Lazara ; Marcussi, Silvana ; Marchi-Salvador, Daniela P.; Silva-Jr, Floriano P. ; Fuly, André L. ; Stábeli, Rodrigo G. ; da Silva, Saulo L. ; González, Jorge ; Monte, Alberto del ; Soares, Andreimar M. . Enzymatic and structural characterization of a basic phospholipase A2 from the sea anemone Condylactis gigantea. Biochimie (Paris. Print), v. 92, p. 1063-1071, 2010.
10. Teixeira, Raquel L.F. ; Silva-Jr, Floriano P.; Silveira, Aline R. ; Cabello, Pedro H. ; Mendonça-Lima, Leila ; Rabahi, Marcelo F. ; Kritski, Afrânio L. ; Mello, Fernanda C.Q. ; Suffys, Philip N. ; de Miranda, Antonio B. . Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. Mutation Research (Print), v. 683, p. 43-49, 2009.
11. Guedes, H. L. M. ; Silva-Jr, Floriano P.; Netto, C. C. ; Salles, C. M. C. ; Alexandre, G. ; Oliveira, C. L. P. ; Torriane, I. L. ; De Simone, S. G. . Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom. Biophysical Chemistry, v. 132, p. 159-164, 2008.
12. Silva-Jr, Floriano P.; ALEXANDRE, G. ; RAMOS, C. I. ; De Simone, S. G. . On the quaternary structure of a C-type lectin from Bothrops jararacussu venom BJ-32 (BjcuL). Toxicon, p. 944, 2008.

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Last Updated: May, 2013