Prof. Xuanyong Lu
Institute of Hepatitis and Virus Research, USA
Email: xuanyong.lu@Drexelmed.edu
Qualifications
1989 Ph.D., Goettingen University, Virology
1982 B.Sc., Nanjing University, Biochemistry
Publications(Selected)
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Pamela Norton, Gong Q. Mehta A, Lu X and Block T. Hepatisis B Virus-mediated changes of apolipaprotein mRNA abundance in cultured hepatoma cells. J. Virol 77(9) 5503-5506.2003.
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Xuanyong Lu, Trang Tran, Ender Semick and Timothy Block. The alkylated imino sugar,n- (n-nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus (HBV) nucleocapsid in tissue culture. J. Virol. 77 (22), 11933-11940. 2003.
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Xuanyong Lu and Block T. Study of the early steps of the Hepatitis B Virus life cycle. Int. J. Med. Sci. 2004, 1(1): 21-33.
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Xuanyong Lu, Paul Weiss and Timothy Block. A phage with high affinity for hepatitis B surface antigen for detection of HBsAg. The Journal of Virological Methods. 119 (1): 51-54, 2004.
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Xuanyong Lu, Matthew Lee, Trang Tran, and Timothy Block. High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis B virus. Int. J. Med. Sci. 2005, 2(1), 44-51.
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Tsurng-Juhn Huang, Cheng-Chan Lu, Jui-Chen Tsai, Wei-Jen Yao, Xuanyong Lu, Ming-Derg Lai, Hsiao-Sheng Liu1, Ai-Li Shiau. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J Biol Chem. 2005, 280: 27742-27754.
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Simsek E, Lu X, Ouzounov S, Block TM, Mehta AS. alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins. Antivir Chem Chemother. 2006; 17(5):259-67.
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Lu X, Lamontagne J, Lu F, Block T. Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis. Apoptosis 2008;13:483-94.
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Jason Lamontagne, Mark Pinkerton, Timothy M. Block and Xuanyong Lu. HCV and HBV replication up-regulate serine protease inhibitor Kazal, resulting in cell resistance to serine protease dependent apoptosis, J. Virol. 2010; 84 907-917.
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Mark Pinkerton, Felix Lu, Jason Lamontagne, Timothy Block and Xuanyong Lu. Suppression of granzyme A mediated apoptosis may be a reason causing the persistent hepatitis B and hepatitis C virus infection and development of liver cancer. 2010, 19th annual Philadelphia infection and immunity forum, Philadelphia. P65.
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Guo, H. Pan, X. Mao, R. Zhang, X. Wang, L. Lu, X. Chang, J. Guo, J. T. Passic, S. Krebs, F. C. Wigdahl, B. Warren, T. K. Retterer, C. J. Bavari, S. Xu, X. Cuconati, A. Block, T. M. Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses. Antimicrob Agents Chemother, 55,478-86, 2011.
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Felix Lu, Jason Lamontagne, Angela Sun, Mark Pinkerton, Timothy Block and Xuanyong Lu, Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A mediated apoptosis. Immunology. 2011, accepted.
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Jason Lamontagne, Courtney Mills, Mark Pinkerton, Richeng Mao, Cally Goddard, Dawei Cai, Haitao Guo,Andy Cuconati, Timothy Block and Xuanyong Lu. Screening and identifying of compounds against hepatitis B virus from safe compound library by high throughput system: real-time immuneprecipitation PCR. In preparation.
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Michael Kann, Xuanyong Lu, Tanja Tolle and Wolfram Gerlich. Late and early steps in the life cycle of hepatitis b virus. Viral Hepatitis and liver disease- proceeding of the IX. International Symposium Rome 1996. M. Rizzetto editor.
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Block, T., Xuanyong Lu, A. Mehta, J. park, B. Blumberg, R. Dwek (1997) Role of glycan processing in the trafficking of HBV in liver cells. Proc. Exp. Biol. & Med. (J. Axford, Ed).
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Xuanyong Lu and Timothy M. Block. Enhancement of infection of HepG2 cells in culture, by pre-digestion of hepadnavirus with V8 protease, Methods in Molecular Medicine. J.Lau ed. The Humana press Inc. CA, USA. 2004, 199-208.
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Xuanyong Lu . Pathogenesis of Hepatitis B virus- mediated liver injury, North American Journal of Medicine and Science, 2011, 4(1) 1-6.
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Gerlich WH. Heermann KH. Lu X. Functions of hepatitis B surface proteins. 1992,Archives of Virology - Supplementum. 4:129-32.
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Block TM. Lu X. Mehta A. Park J. Blumberg BS. Dwek R. Role of glycan processing in hepatitis B virus envelope protein trafficking. Advances in Experimental Medicine &Biology. 435:207-16, 1998.