Biography

Dr. Zhiwei Hu

College of Medicine, Department of Surgery

The OSU James Comprehensive Cancer Center

The Ohio State University

Associate Professor


Email: zhiwei.hu@osumc.edu


Qualifications

1997 Ph. D., Hunan Medical University, Tumor Immunobiology

1994 M. S., Jiangxi Medical College, Tumor Immunology

1991 M. D., Jiangxi Medical College, Medicine and Stomatology


Publications (selected)

  1. Jijun Cheng, Jie Xu, Jinzhong Duanmu, Han Zhou, Carmen J. Booth and Zhiwei Hu *. (2011) Effective treatment of human lung cancer by targeting tissue factor with a factor VII-targeted photodynamic therapy. Current Cancer Drug Targets. 11(9): 1069-1081.
  2. Jinzhong Duanmu, Jijun Cheng, Jie Xu, Carmen J. Booth and Zhiwei Hu* (2011). Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. British Journal of Cancer. 104(9): 1401-1409. PMID: 21427724.
  3. Zhiwei Hu*, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2011) Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer. Breast Cancer Research and Treatment. 126(3):589-600 June 1 2010 PMID: 2051451.
  4. Zhiwei Hu* and Jing Li (2010). Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunology. 2010, 11(1):49 PMCID: PMC2965132. This article has been labeled as “Highly Accessed” by the Journal and is publicly available at http://www.ncbi.nlm.nih.gov/pubmed/20939894.
  5. Zhiwei Hu*, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice. BMC Cancer. 2010, 10:235 PMCID: PMC2882923.This article is publicly available at http://www.ncbi.nlm.nih.gov/pubmed/20504328.
  6. Emiliano Cocco, Zhiwei Hu*, Christine E. Richter, Stefania Bellone, Francesca Casagrande, Marta Bellone, Paola Todeschini, Graciela Krikun, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli, Charles J. Lockwood, and Alessandro D. Santin*. (2010) hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma. British Journal of Cancer. 103(6):812-9 PMID: 20700124.
  7. Graciela Krikun*, Zhiwei Hu*, Kevin Osteen, Kaylon Tran-Brunner, Frederick Schatz, Hugh S. Taylor, Paolo Toti, Felice Arcuri, William Konigsberg, Alan Garen, Carmen J. Booth, and Charles J. Lockwood. (2010) Targeting Tissue Factor with the Immunoconjugate “Icon” Leads To the Regression of Endometriosis Through Destruction of Aberrant Blood Vessels. American Journal of Pathology 176(2):1050-1056 PMID: 20042667.
  8. Fang Lu, Zhiwei Hu*, John Sinard, Alan Garen, and Ron A Adelman*. (2009) Factor VII–verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal Neovascularization. Investigative Ophthalmology & Visual Science. 50(8): 3890-6. PMID: 19357351.
  9. Joseph S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La Jeunesse, Matthew J. Flick, Keith W. Kombrinck, Zhiwei Hu, Kelley A. Barney, and Jay L. Degen. (2007) Tumor cell-expressed tissue factor and circulating coagulation factors cooperatively increase metastatic potential through natural killer cell-dependent and -independent mechanisms. Blood. 110(1):133-41 PMCID: PMC1896107.
  10. Tongalp H. Tezel, Ewa Bodek, Kenan Sönmez, Sankar Kaliappan, Henry J. Kaplan, Zhiwei Hu, Alan Garen. (2007) Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal injection of factor VII-IgG1 Fc chimeric antibody. Ocular Immunology and Inflammation. 15: 3-10.
  11. Yucheng Tang, Per Borgstrom, Jonathan Maynard, Zhiwei Hu, Alan Garen, and Albert Deisseroth. (2007) Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Therapy. 14: 346-353.
  12. Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong- Hyeon Sohn, Shin Goo Kang, Jose M. Cruz, Nalini S. Bora, Alan Garen and Henry J. Kaplan. (2003) Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA. 100: 2679-2684 PMCID: PMC151400.
  13. Xu Song, Baiyang Wang, Michael Bromberg, Zhiwei Hu, William Konigsberg and Alan Garen. (2002) Retroviral-mediated transmission of a mouse VL30 RNA to human melanoma cells promotes metastasis in an immunodeficient mouse model. Proc. Natl. Acad. Sci. USA. 99: 6269-6273 PMCID: PMC122938.
  14. Zhiwei Hu and Alan Garen. (2001) Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc. Natl. Acad. Sci. USA. 98:12180-12185 PMCID: PMC59788. This article has attracted wide publicity in the press in 2001 and has been cited as one of novel cancer therapies for “Cancer Treatment: Present and Future” in Molecular Biology of the Cell (Alberts, Bruce 4th ed.) in 2002.
  15. Jiangao Zhu, Guanchen Li, YH Li, Jinyue Hu, Guohua Zhou, Zhiwei Hu, Qubing Sun and Xiaolin Li. (2001) Cloning and expression of human anti-colon cancer single-chain Fv fragment. Chinese J. Biotechnology 17(5):526-30.
  16. Zhiwei Hu and Alan Garen. (2000) Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc. Natl. Acad. Sci. USA. 97: 9221-9225. PMCID:PMC16849.
  17. Zhiwei Hu, Ying Sun and Alan Garen. (1999) Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc. Natl. Acad. Sci. USA. 96: 8161-8166 PMCID: PMC22205.
  18. Zhiwei Hu, Zhaojun Duan, Jiangao Zhu, Guohua Zhou, Jingyue Hu and Qubing Sun. (1999) VH and shorter fragments with antigen-binding activities biopanned from human repertoire single-chain Fv libraries. Chinese J Immunol.15: 148-150.
  19. Zhiwei Hu, Xiaolin Li, Guohua Zhou, Jiangao Zhu, Qubing Sun. (1998) Extraction affinity purification and biological characteristics of colorectal cancer-associated antigen CA-Hb3. Chinese J. of Pathophysiology. 14(4): 363-367.
  20. Zhiwei Hu, Xiaolin Li, Xiaohong Cai, Jiangao Zhu, Guohua Zhou and Qubing Sun. (1997) Cloning immunoglobulin genes from peripheral blood lymphocytes after in vitro immunization. Progress in Biochem and Biophys. 24(5): 458-461.
  21. Zhiwei Hu and Qubing Sun. (1997) Repertoire antibody library constructed from human peripheral blood lymphocytes with in vitro immunization with colorectal carcinoma-associated antigen. Chinese J Cancer Biotherapy. 4(2):130-133.
  22. Zhiwei Hu, Shuyun Wu and Gansheng Wen. (1995) Establishment of an enzyme-linked immunosorbent assay with a monoclonal antibody AU14-1 detecting soluble antigen of cervical carcinoma. Acta Academiae Medicinae Jiangxi. 35(3):9-13.

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