Biography

Dr. Robert W. Malone

Kennesaw State University, USA

Adjunct Associate Professor

Uniformed Services University of the Health Sciences, USA

Adjunct Associate Professor

University of Maryland, USA

Assistant Professor

University of California, USA

Assistant Professor


Email: rwmalonemd@gmail.com


Qualifications

1991 Doctor of Medicine, Northwestern University, USA

1988 Master of Science, University of California, USA

1984 Bachelor of Science, University of California, USA


Publications (selected)

  1. Byrnes CK, Malone RW, Akhter N, Nass PH, Wetterwald A, Cecchini MG, Duncan MD, Harmon JW.  Electroporation enhances transfection efficiency in murine cutaneous wounds. Wound Repair Regen. 2004 Jul-Aug;12(4):397-403.
  2. Glasspool-Malone J, Steenland PR, McDonald RJ, Sanchez RA, Watts TL, Zabner J, Malone RW.  DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. J Gene Med. 2002 May-Jun;4(3):323-2.
  3. Glasspool-Malone J. and Malone RW. Enhancing direct in vivo transfection with nuclease inhibitors and pulsed electrical fields. Methods in Enzymology-Gene Therapy Methods 2002;346:72-91. PMID: 11883098.
  4. Glasspool-Malone J, Peter Steenland, Ruth McDonald, Rigoberto Sanchez, Tamara Watts, Joseph Zabner and Malone RW, Marked enhancement of macaque respiratory tissue transfection by aurintricarboxylic acid. J Gene Med. 2002 May-Jun;4(3):323-2.
  5. Drabick, J.J., Glasspool-Malone J., Somiari S., King A., Malone RW. Increased efficiency of cutaneous transfection and polynucleotide immunization using in-vivo electroporation. MolTher 2001 Feb, 3(2). 249 – 255.
  6. Somiari S, Glasspool-Malone J, Drabick JJ, Gilbert RA, Heller R, Jaroszeski MJ, Malone RW. Theory and in vivo application of electroporative gene delivery.MolTher. 2000 Sep;2(3):178-87.
  7. Glasspool-Malone J, Somiari S, Drabick JJ, Malone RW. Efficient nonviral cutaneous transfection. MolTher. 2000 Aug;2(2):140-6.
  8. Colosimo A, Goncz KK, Holmes AR, Kunzelmann K, Novelli G, Malone RW, Bennett MJ, Gruenert DC.  Transfer and expression of foreign genes in mammalian cells. Biotechniques. 2000 Aug;29(2):314-8, 320-2, 324 passim.
  9. Ahearn A, Malone RW. Models of Cationic Liposome Mediated Transfection. Gene Therapy and  Molecular Biology (Dec., 1999) Vol 4.
  10. Kisich KO, Malone RW, Feldstein PA, Erickson, KL. Specific inhibition of macrophage TNF-alpha expression by In vivo ribozyme treatment. Journal of Immunology (1999)163(4):2008-16.
  11. Glasspool-Malone J, Malone RW, “Marked Enhancement of Direct Respiratory Tissue Transfection by Aurintricarboxylic Acid”. Human Gene Therapy (1999) 10:1703-1713.
  12. Berlyn KA, Ponniah S, Stass SA, Malone JG, Hamlin-Green G, Lim JK, Fox M, Tricot G, Alexander RB, Mann DL, and Malone RW. Developing Dendritic Cell Polynucleotide Vaccination for Prostate Cancer Immunotherapy. J. of Biotechnology (1999) 73:155-179.
  13. Bennett MJ, Aberle AM, Balasubramaniam RP, Malone JG, Malone RW,Nantz MH.  Cationic lipid mediated gene delivery to murine lung: correlation of polar domain structure with in vivo transfection activity. J. Med. Chem. (1997) 40(25), 4069-4078.
  14. Malone JG, Bergland P, Liljestrom P, Rhodes, GH, Malone RW. Mucosal immune responses associated with polynucleotide vaccination. Behring Inst. Mitt. (1997)  98, 63-72.
  15. Freedland SJ, Malone RW, Borchers HM, Zadourian Z, Malone JG, Bennett MJ, Nantz MH, Juan-Hua L, Gummerlock PH, Erickson KL. Toxicity of cationic lipid-ribozyme in human prostate tumor cells can mimic ribozyme activity. Biochem. and Molecular Medicine.  (1996) 59,144-153.
  16. Bennett MJ, Aberle AM, Balasubramaniam RP, Malone JG, Nantz MH, Malone RW. Considerations for the design of improved cationic amphiphile-based transfection reagents. Journal of Liposome Research (1996) 6(3), 545-565.
  17. Aberle AM, Bennett MJ, Malone RW, Nantz MH. The counterion influence on cationic lipid-mediated transfection of plasmid DNA. Biochemica et BiophysicaActa (1996) 1299(3), 281-283.
  18. Balasubramaniam RP, Bennett MJ, Aberle AM, Malone JG, Nantz MH, Malone RW. Structural and functional analysis of cationic transfection lipids:  the hydrophobic domain. Gene Therapy (1996) 3(2)163-172.
  19. Montbriand P and Malone RW. An Improved method for the removal of endotoxin from DNA.
  20. J Biotechnol. 1996 Jan 26;44(1-3):43-6.
  21. Hickmann MA, Malone RW,Sih TR, Akita GY, Powell JS.  Hepatic gene expression after direct DNA injection. Advanced Drug Delivery Reviews (1995) 17(3), 265-271.
  22. Schenborn E, Oler J, Goiffon V, Balasubraniam R, Bennett M, Aberle A, Nantz M, Malone RW.Tfx-50 Reagent, a new transfection reagent for eukaryotic cells. Promega Notes (1995) 52, 2-7.
  23. Bennett MJ, Nantz MH, Balasubraniam RP, Gruenert D, Malone RW.  Cholesterol enhances cationic liposome-mediated DNA transfection of human respiratory epithelial cells. Bios Reports (1995) 15, 47-53.
  24. Bennett MJ, Nantz MH, Malone RW. A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection. Tetrahedron Letters (1995) 36(13), 2207-2210.
  25. Malone RW,Hickmann MA, Lehmann-Gruinsma K, Sih TR, Walzem R, Carlson D, Powell JS. Dexamethasone enhancement of gene expression after direct hepatic DNA injection. Journal of Biological Chemistry (1994) 269(47), 29903-29907.
  26. Hickmann MA, Malone RW, Lehmann K, Sih TR, Knoell D, Szoka FC, Walzem R, Carlson DM, Powell JS. Gene expression following direct injection of DNA into liver. Human Gene Therapy (1994) 5, 1477-1483.
  27. Dwarki VJ, Malone RW, Verma IM. Cationic liposome mediated RNA transfection. Methods in Enzymology (1993) 217, 644-654.
  28. Wolff J, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner P.  Direct gene transfer into mouse muscle in vivo. Science (1990) 247, 1465-1468.
  29. Malone RW. mRNA Transfection of cultured eukaryotic cells and embryos using cationic liposomes. Focus (1989) 11, 61-66.
  30. Malone RW,Felgner P, Verma I. Cationic Liposome Mediated RNA Transfection. Proceedings of the National Academy of Science USA 86(16), 6077-6081.
  31. Gardner MB, Malone RW, Morris D, Young L, Strange R, Cardiff R, Faulkin L, Mitchell D. Mammary tumors in feral mice lacking MuMTV DNA. Journal of Experimental Pathology 2(2), 93-98.
  32. Faulkin L, Mitchell D, Young L, Morris D, Malone R, Cardiff R, Gardner M. Hyperplastic and neoplastic changes in the mammary glands of feral mice free of endogenous mouse mammary tumor virus provirus. Journal of the National Cancer Institute (1984) 73(4), 971-982.

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