Prof. Tarek Aboul-Fadl

Department of Medicinal Chemistry, Faculty of Pharmacy

Assiut University, Egypt

Professor

Email: Fadl@aun.edu.eg, tarekaboulfadl@yahoo.com

Qualifications

1994 Ph.D., Pharmaceutical Medicinal Chemistry, Assiut University-Josai University, Egypt

1989 M.S., Pharmaceutical chemistry, Assiut University, Egypt

1984 B.S., Pharmaceutical Sciences, Assiut University, Egypt

Publications (Selected)

1. Aboul-Fadl T., Abdel-Aziz H.A., Kadi A., Ahmad P., Elsaman T., Attwa M.W. and Darwish I. A. (2011), Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of Combinatorial Library of Indolin-2,3-Dione Schiff Bases with Potential Antimycobacterial Activity, molecules, 16, 5194-5206.
2. Aboul-Fadl T., Sheha M. M., El-Azab A. and Abdel-Aziz H.A. (2011), Amantadine Amides Prodrugs as Hepatic Delivery Systems to Enhance its Activity Against HCV, Digest Journal of Nanomaterials and Biostructures, 6, 1675-1683.
3. Aboul-Fadl T., Abdel-Aziz H.A., Abdel-Hamid M.A., Elsaman T., Thanassi J. and Pucci M. J. (2011), Schiff Bases of Indoline-2,3-Dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase, molecules, 16, 7864-7879.
4. Kempe-Dustin J. J., Aboul-Fadl T., Christensen C., Palais R., Parsawar K., Gleich G.J. and Wagner L.A. (2011), Cell Screening Assay for Identifying Inhibitors of Eosinophil Proliferation, Drug Development Research, 72, 2-8.
5. El-Sayed W. M., Aboul-Fadl T. and Franklin M. R. (2010), Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice, Drug Development Research, 71, 313-322.
6. Aboul-Fadl T., Bin-Jubair F. A. S. and Aboul-Wafa O. (2010), Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives and Nalidixic Acid Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric Model Building, Eur. J. Med. Chem. 45, 4578-4586.
7. Sarhan A. A. O., Al-Dhfyan A., Al-Mozaini M. A., Adra C. N. and Aboul-Fadl T. (2010), Cell Cycle Disruption and Apoptotic Activity of 3-Aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues, Eur. J. Med. Chem., 45, 2689-2694.
8. Abdel-Aal W. S., Hassan H. Y., Aboul-Fadl T. and Youssef A. F. (2010), Pharmacophoric Model Building for Antitubercular Activity of the Individual Schiff Bases of Small Combinatorial Library, Eur. J. Med. Chem., 45, 1098-1106.
9. Darwish I. A., Mahmoud A. M., Aboul-Fadl T., Al-Majed A.A. and Khalil N. Y.(2009), A highly sensitive enzyme immunoassay for evaluation of 2_-deoxycytidine plasma level as a prognostic marker for breast cancer chemotherapy, Analytica Chimica Acta, 632, 266–271.
10. Aboul-Fadl T., Kallanthottathil G. R. and Broom A. D. (2008), Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-mercaptopurine Base, J. Heterocyclic Chem., 45,445-451.
11. Franklin M. R., Moos P. J., El-Sayed W. M., Aboul-Fadl T. and Roberts J.C. (2007), Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse, Chem-Biol Interactions, 168, 211–220.
12. El-Sayed W.M., Aboul-Fadl T., Roberts J. C., Lamb J. G. and Franklin M. R. (2007), Murine Hepatoma (Hepa1c1c7) Cells: A Responsive In Vitro System for Chemoprotective Enzyme Induction by Organoselenium Compounds, Toxicology in Vitro, 21, 157-164.
13. Aboul-Fadl T. (2006), Antisense Oligonucleotide Technologies in Drug Discovery, Expert Opin. Drug Discov., 1, 285-288.
14. Deutch C., Arballo M., Cooks L., Gomes J., Williams T., Aboul-Fadl T. and Roberts J. (2006), Sensitivity of Escherichia coli to L-selenaproline and other L-proline analogues in laboratory culture media and normal. human urine, Letters in Applied Microbiology, 43, 392–398.
15. El-Sayed W. M., Aboul-Fadl T., Lamb J. G., Roberts J. C. and Franklin M. R. (2006), Acute Effects of Novel Selenazolidines on Murine Chemoprotective Enzymes, Chemico-Biological Interactions, 162, 31-42.
16. El-Sayed W. M., Aboul-Fadl T., Lamb J. G., Roberts J. C. and Franklin M. R. (2006), Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice, Toxicology, 220, 179–188.
17. Rabea S. M., El-Koussi N. A., Hassan H. Y. and Aboul-Fadl T. (2006), Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives of Potential Anti-inflammatory Activity, Archiv der Pharmazie, 339, 32-40.
18. Aboul-Fadl T. (2005), Selenium Derivatives as Cancer Preventive Agents, Current Medicinal Chemistry-Anti-Cancer Agents, 5, 637-52.
19. Aboul-Fadl T. (2005), Antisense Oligonucleotides: The State of the Art, Current Medicinal Chemistry, 12, 2193-2214.
20. Aboul-Fadl T., Agrawal V. K., Buckheit Jr. R. W. and Broom A. D. (2004), An Unusual “Senseless” 2’-5’ Oligoribonucleotide with Potent Anti-HIV Activity. Nucleosides, Nucleotides & Nucleic Acids, 23, 545-554.
21. Mahmoud S., Aboul-Fadl T., Sheha M., Farag H. H. and Mouhamed A.I. (2003), 1,2-Dihydroisoquinoline-N-Acetic Acid Derivatives as New Carriers for Specific Brain Delivery I : Synthesis and Estimation of Oxidation Kinetics Using Multivariate Calibration Method, Arch. Pharm.Pharm. Med. Chem., 336, 573-584.
22. Löber S., Aboul-Fadl T., Hübner H. and Gmeiner P.(2002), Di- and Trisubstituted Pyrazolo[1,5-a]pyridine Derivatives: Synthesis, Dopamine Receptor Binding and Ligand Efficacy, Bioorganic and Medicinal Chemistry Letters, 12, 633-636.
23. Abdel-Hafez A.A., Meselhy M. R., Nakamura N., Hattori M., El-Gendy M. A., Mahfouz N. M. and Mohamed T. A. (2001), New Paeonilactone-A-Adducts Formed by Incubation of Paeoniflorin with Lactobacillus brevis in Presence of Arylthiols, Chem. Pharm. Bull., 49, 918-920.
24. Aboul-Fadl T., Löber S. and Gmeiner P. (2000), Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving Palladium-Catalyzed Coupling Reactions, Synthesis,12, 1727-1732.