Prof. Reinhard Heun

University of Bonn, Germany

Email: heun@gmx.com

Qualifications

1985  Medical Doctorate (MD), University of Würzburg, Germany

1982  Diploma in Biology (Biochemistry), University of Göttingen

1976  Baccalaureate, Corvinianum Northeim, Germany

Publications (Selected)

1.     Belbin O, Brown K, Shi H, Medway C, Abraham R, Passmore P, Mann D, Smith AD, Holmes C, McGuinness B, Craig D, Warden D, Heun R, Kölsch H, Love S, Kalsheker N, Williams J, Owen MJ, Carrasquillo M, Younkin S, Morgan K, Kehoe PG. (2011) A Multi-Center Study of ACE and the Risk of Late-Onset Alzheimer's Disease. J Alzheimers Dis. 2011 Feb 1.

2.     Weis S, Leube D, Erb M, Heun R, Grodd W, Kircher T. (2011) Functional Neuroanatomy of Sustained Memory Encoding Performance in Healthy Aging and in Alzheimer's Disease. Int J Neurosci. 2011 Mar 29.

3.     Kölsch H, Heun R, Jessen F, Popp J, Hentschel F, Maier W, Lütjohann D (2010) Alterations of cholesterol precursor levels in Alzheimer's disease. Biochim Biophys Acta. 1801(8):945-50.

4.     Lehmann DJ, Schuur M, Warden DR, Hammond N, Belbin O, Kölsch H, Lehmann MG, Wilcock GK, Brown K, Kehoe PG, Morris CM, Barker R, Coto E, Alvarez V, Deloukas P, Mateo I, Gwilliam R, Combarros O, Arias-Vásquez A, Aulchenko YS, Ikram MA, Breteler MM, van Duijn CM, Oulhaj A, Heun R, Cortina-Borja M, Morgan K, Robson K, Smith AD. (2010) Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. Neurobiol Aging. 2010 Sep 1. [Epub ahead of print].

5.     Combarros O, Warden DR, Hammond N, Cortina-Borja M, Belbin O, Lehmann MG, Wilcock GK, Brown K, Kehoe PG, Barber R, Coto E, Alvarez V, Deloukas P, Gwilliam R, Heun R, Kölsch H, Mateo I, Oulhaj A, Arias-Vásquez A, Schuur M, Aulchenko YS, Ikram MA, Breteler MM, van Duijn CM, Morgan K, Smith AD, Lehmann DJ. (2010) The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. BMC Med Genet 11:162.

6.     Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ. (2010) Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiol Aging. 31(6):901-9 (IF 6.0).

7.     Heun R, Gühne U, Luck T, Angermeyer MC, Ueberham U, Potluri R, Natalwala A, Arendt T, Riedel-Heller SG (2010) Apolipoprotein E allele 4 is no sufficient or necessary predictor of the development of Mild Cognitive Impairment. European Psychiatry 25(1):15-8 (IF 3.1).

8.     Carrasquillo MM, Belbin O, Zou F, Allen M, Ertekin-Taner N, Ansari M, Wilcox SL, Kashino MR, Ma L, Younkin LH, Younkin SG, Younkin CS, Dincman TA, Howard ME, Howell CC, Stanton CM, Watson CM, Crump M, Vitart V, Hayward C, Hastie ND, Rudan I, Campbell H, Polasek O, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Kehoe PG, Mann DM, Smith AD, Beaumont H, Warden D, Holmes C, Heun R, Kölsch H, Kalsheker N, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Wright AF, Younkin SG, Morgan K. (2010) Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PLoS One. 2010 Jan 19;5(1):e8764.

9.     Combarros O, van Duijn CM, Hammond N, Belbin O, Arias-Vásquez A, Cortina-Borja M, Lehmann MG, Aulchenko YS, Schuur M, Kölsch H, Heun R, Wilcock GK, Brown K, Kehoe PG, Harrison R, Coto E, Alvarez V, Deloukas P, Mateo I, Gwilliam R, Morgan K, Warden DR, Smith AD, Lehmann DJ. (2009) Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J Neuroinflammation 6: 22-31.

10.   Frangou S, Gorwood P, Heun R (2009). Foreword to the special issue on forensic psychiatry. Eur Psychiatry. 24:353 (IF 2.4).

11.   Hong GS, Heun R, Jessen F, Popp J, Hentschel F, Kelemen P, Schulz A, Maier W, Kölsch H. (2009) Gene variations in GSTM3 are a risk factor for Alzheimer's disease. Neurobiol Aging 30:691-6. (IF 6.0).

12.   Jessen F, Gür O, Block W, Ende G, Frölich L, Hammen T, Wiltfang J, Kucinski T, Jahn H, Heun R, Maier W, Kölsch H, Kornhuber J, Träber F. A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI. Neurology. 2009;72:1735-40 (IF 7.5).

13.   Klotz L, Schmidt S, Heun R, Klockgether T, Kölsch H (2009) Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis. Neurosci Lett. 449: 81-83 (IF 2.6).

14.   Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Friedrichs S, Maier W, Heun R. (2009) RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism. J Cell Mol Med 13:589-98 (IF 5.1).

15.   Kölsch H, Lütjohann D, Jessen F, Popp J, Hentschel F, Kelemen P, Schmitz S, Maier W, Heun R (2009) CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. Eur Psychiatry 24:183-90 (IF 2.4).

16.   Potluri R, Natalwala A, Uppal H, Heun R. (2009) Different Risk Factors in Vascular Dementia and Ischaemic Stroke. Neuroepidemiology. 32:80 (IF 1.7).

17.   Qureischie H, Heun R, Popp J, Jessen F, Maier W, Schmitz S, Hentschel F, Kelemen P, Kölsch H (2009) Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions. J Neural Transm. 116:467-72 (IF 2.5).

18.   Upadhyaya T; Mathew P; Potluri R; Natalwala A; Uppal H; Narendran P; Heun R. Pneumonia is a predictor of mortality in patients with multiple sclerosis. 13th Congress of the European-Federation-of-Neurological-Societies. 16:266-266. (Oct 2009).

19.   Upadhyaya T; Mathew PA; Potluri R; Natalwala A; Uppal H; Narendran P; Heun R. Pneumonia is a predictor of mortality in patients with multiple sclerosis. Lecture, 19th Meeting of the European-Neurological-Society. 256:S10-S10. (Jun 2009).

20.   Potluri R; Natalwala A; Narendran P; Heun R. Diabetes mellitus and dementia-A putative link?. 5th International Congress on Vascular Dementia. 283:304-305. (15 Aug 2009).

21.   Abdulrab K, Heun R (2008) Subjective memory impairment. A review of its definitions indicates the need for a comprehensive set od standardised and validated criteria. European Psychiatry 23: 321-30 (IF 2.4).

22.   R.Potluri, ; H.S.Uppal ; A.Natalwala,. ; P.Narendran, ; R.Heun. (2008). Prevalence of mental health disorders and Parkinson’s disease. Parkinsonism and Related Disorders. 14:s279.

23.   Potluri R; Uppal HS; Natalwala A; Narendran P; Heun R. (Apr 2008). The prevalence of mental health disorders in Parkinsons disease. EUR PSYCHIAT. 23:S279-S279.

24.   Potluri R; Natalwala A; Uppal HS; Narendran P; Heun R. The prevalence of mental health disorders in Parkinson's disease. 12th Congress of the European-Federation-of-Neurological-Societies. 15:128-128. (Aug 2008).

25.   Natalwala A; Potluri R,; Uppal H, ; Narendran P, ; Heun R. (2008). Reasons for hospital admissions in dementia patients during 2002-2007. Clinical Neurophysiology. 119:s128-s129.