Dr. Lbachir BenMohamed

The Gavin Herbert Eye Institute & Institute for Immunology

University of California Irvine, USA

Associate Professor

Email: Lbenmoha@uci.edu

Qualifications

1997 Ph.D., Immunology, Pasteur Institute & Paris VII University, France

1990 M.S., Molecular Biology and Biochemistry, Paris VI University, France

Publications (selected)

1. Bossus M,BenMohamed L, Londono A, Barbier B, Tartar A, Druilhe P, Gras-Masse H. Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues.Journal of Peptide Science.1997. Jan-Feb;3(1):47-53.
2. Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B,BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature Medicine.2000.6(11):1258-63.
3. BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response.Human Immunology.2000.61(8):764-79.
4. BenMohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules.Vaccine.2000.18(25):2843-55.
5. Brahimi K, Badell E, Sauzet JP,BenMohamed L, Daubersies P, Guérin-Marchand C, Snounou G, Druilhe P. Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo.Infection and Immunity.2001.69(6):3845-52.
6. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J,BenMohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, Wechsler SL. A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Journal of Virology.2002.76(16):8003-10.
7. BenMohamed L, Wechsler SL, Nesburn AB. Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infectious Diseases.2002.2(7):425-31.
8. BenMohamed L, Belkaid Y, Loing E, Brahimi K, Gras-Masse H, Druilhe P. Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. European Journal of Immunology.2002.32(8):2274-81.
9. BenMohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology.2002.106(1):113-21.
10. Vichier-Guerre S, Lo-Man R,BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. Journal of Peptide Research.2003.62(3):117-24.
11. BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL, Nesburn AB. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity.Journal of Virology.2003.77(17):9463-73.
12. Zhu X, Ramos TV, Gras-Masse H, Kaplan BE,BenMohamed L. Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity.European Journal of Immunology.2004.4(11):3102-14.
13. Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V,BenMohamed L, Diop OM, Livingston PO, Bay S, Leclerc C. A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates.Cancer Research.2004.64(14):4987-94.
14. BenMohamed L, Thomas A, Druilhe P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides.Infection and Immunity.2004. 72(8):4376-84.
15. Peng W, Henderson G, Inman M,BenMohamed L, Perng GC, Wechsler SL, Jones C. The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice.Journal of Virology.2005.79(10):6162-71.
16. Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V,BenMohamed L. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant.Vaccine.2005.23(7):873-83.
17. Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB,BenMohamed L. Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection.Journal of Virology.2005.79(24):15289-301.
18. Bettahi I, Zhang X, Afifi RE,BenMohamed L. Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response. Viral Immunology.2006.19(2):220-36.
19. Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL,BenMohamed L. Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system.Ocular Surface.2006.4(4):178-87.
20. Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL,BenMohamed L. Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.Journal of Virology.2007.81(14):7647-61.

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