Prof. Rolf König

Department of Microbiology & Immunology

The University of Texas Medical Branch, USA

Email: rokonig@utmb.edu

Qualifications

1984 Ph.D., Biology, University of Bern, Switzerland

1980 M.S., Biology, University of Bern, Switzerland

1978 B.S., Zoology with Physics, Chemistry, and Biochemistry as minor subjects, University of Bern, Switzerland

Publications (selected)

1. R. König, H. Kindle, J.G. Kunkel, and B. Lanzrein (1988) Vitellogenesis in the cockroachNauphoeta cinerea: Separation of two classes of ovarian binding sites and calcium effects on binding and uptake. Arch. Insect Biochem. Physiol. 9: 323-338.
2. R. König, G. Ashwell, and J.A. Hanover (1988) Glycosylation of CD4: Tunicamycin inhibits surface expression. J. Biol. Chem. 263: 9502-9507.
3. R. König, G. Ashwell, and J.A. Hanover (1989) Overexpression and biosynthesis of CD4 in Chinese hamster ovary cells: Coamplification using the multiple drug resistance gene. Proc. Natl. Acad. Sci. U.S.A. 86: 9188-9192.
4. R. König, L.-Y. Huang, and R. N. Germain (1992) MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature 356: 796-798.
5. R. König, X. Shen, and R. N. Germain (1995) Involvement of both MHC class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. J. Exp. Med. 182: 779-787.
6. R. König, S. Fleury, and R. N. Germain (1996) The structural basis of CD4-MHC class II interactions: Coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. Curr. Top. Microbiol. Immunol. 205: 19-46.
7. X. Shen, B. Hu, P. McPhie, X. H. Wu, A. Fox, R. N. Germain, and R. König (1996) Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytesin vitroandin vivo. J. Immunol. 157: 87-100.
8. D. P. Metz, D. L. Farber, R. König, and K. Bottomly (1997) Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction. J. Immunol. 159: 2567-2573.
9. X. Shen and R. König (1998) Regulation of T cell immunity and tolerancein vivoby CD4. Int. Immunol. 10: 247-257.
10. S. Gilfillan, X. Shen, and R. König (1998) Selection and function of CD4+ T lymphocytes in transgenic mice expressing mutant MHC class II molecules deficient in their interaction with CD4. J. Immunol. 161: 6629-6637.
11. L. Wang, J. J. Y. Chen, B. B. Gelman, R. König, and M. W. Cloyd (1999) A novel mechanism of CD4 lymphocyte depletion involves HIV’s effects on resting lymphocytes: induction of lymph node homing and apoptosis upon secondary signaling through homing receptors. J. Immunol. 162: 268-276.
12. R. Maroto, X. Shen, and R. König (1999) Requirement for efficient interactions between CD4 and MHC class II molecules for survival of resting CD4+ T lymphocytesin vivoand for activation-induced cell death. J. Immunol. 162: 5973-5980.
13. X. Shen and R. König (2001) Post-thymic selection of peripheral CD4+ T lymphocytes on class II major histocompatibility antigen-bearing cells. Cell. Mol. Biol. 47: 87-96.
14. X. Shen, K. Lee, and R. König (2001) Effects of heavy metal ions on resting and antigen-activated CD4+ T cells. Toxicology 169: 67-80.
15. K. Lee, X. Shen, and R. König (2001) Effects of cadmium and vanadium ions on antigen-induced signaling in CD4+ T cells. Toxicology 169: 53-65.
16. R. König, X. Shen, R. Maroto, and T. L. Denning (2002) The role of CD4 in regulating homeostasis of T helper cells. Immunol. Res. 25:115-130.
17. R. König (2002) Interactions between MHC molecules and co-receptors of the TCR. Curr. Opin. Immunol. 14: 75-83.
18. W. Zhou and R. König (2003) T cell receptor-independent CD4 signaling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Cell. Signal. 15: 751-762.
19. T. L. Denning, H. Qi, R. König, K. G. Scott, M. Naganuma, and P. B. Ernst (2003) CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC. J. Immunol. 171: 2279-2286.
20. R. König and W. Zhou (2004) Signal transduction in T helper cells: CD4 coreceptors exert complex regulatory effects on T cell activation and function. Curr. Issues Mol. Biol. 6: 1-15.

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