First Otoliths/Collagen/Bacterial Cellulose Nanocomposites as a Potential Scaffold for Bone Tissue Regeneration

G.M Olyveira, Daisy Pereira Valido, L.M.M. Costa, Plácia Barreto Prata Gois, Lauro Xavier Filho, Pierre Basmaji

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DOI: 10.4236/jbnb.2011.23030                

Abstract

In the present work, we report the first bionanocomposite material formed by otoliths/ collagen/ bacterial cellulose (BC) networks (OCBC). This biomaterial is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone tissue regeneration mainly because nanotolith are rich in minerals considered essential to the bone mineralization process on a protein matrix (otolin). The objective in this study was to analyze the regeneration capacity of bone defects treated with this bionanocomposite. Histological experiments shows bone tissue formation with high regularity, higher osteoblast activity and osteo-reabsorption activities areas. The results suggest the potential for this new biomaterial as a scaffold for bone tissue regeneration.

Keywords

bacterial cellulose, natural composites, bionanocomposites, tissue engineering, bone tissue regeneration

Conflicts of Interest

The authors declare no conflicts of interest.

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