Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant

Nihad Abdel-Monem, Ahmed M. Abdel-Azeem, E. S. H. El Ashry, Doaa A. Ghareeb, Asmaa Nabil-Adam

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
Department of Organic Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
Laboratory of Systemic Mycology, Department of Botany, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Marine Environmental Division, National Institute of Oceanography and Fisheries (NIOF) Marine Biotechnology and Natural Product (MBNP), Alexandria, Egypt.

DOI: 10.4236/ojmc.2013.33009                

Abstract

Marine derived fungi are considered as a promising source of novel drugs due to their biodiversity and consequent chemo-diversity. Although marine microorganisms especially fungi are not well defined taxonomically, making this a promising frontier for the discovery of new medicines. This study focused on marine derived fungi as a model for bioactive exploration for new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid (TBARS),α,α-Diphenyl-β- picrylhydrazyl (DPPH) and NO assay are based on their total phenolic and flavonoid content of each extract group. Ch. globosum recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording 59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO inhibition assay, N. oryzae showed 49.3% comparing with ascorbic acid (73.12%). From the preliminary result of our extracts, we can consider the marine derived fungi extracts as promising antioxidant and anti-inflammatory drug candidate.

Keywords

DPPH; TBARS; Marine Drugs; Marine Derived Fungi; Anti-Inflammatory; Antioxidant Capacity

Conflicts of Interest

The authors declare no conflicts of interest.

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