Dr. Xiufen Zheng

Lawson Institute of Health Research

University of Western Ontario, Canada

Assistant professor

Email: xzheng 26@uwo.ca, zhengxf007@gmail.com (preferred), XiufenZheng@lawsonResearch.com

Qualifications

2003 Ph.D Biochemistry & molecular Biology, China Agricultural University, China

1990 M.Sc. Biochemistry, China Agricultural University, China

1987 B.Sc. Biochemistry & Physiology, China Agricultural University, China

Research Fields

Genetics

Oncology

Immunology

Ischemia reperfusion injury

Publications (selected)

1. Shan W, Ablimit A, Zhou W, Zhang F, Ma Z, Zheng X. Genetic polymorphism of 17 Y chromosomal STRs in Kazakh and Uighur populations from Xinjiang, China. Int J Legal Med. 2014 Jan 8. [Epub ahead of print].  correspondence author.
2. Wenjuan Shan, Zhijuan Ren, Weiwei Wu, Hongmei Hao, Abdurrahman Abulimiti, Kaixu Chen, Fuchun Zhang, Zhenghai Ma, Xiufen Zheng*. Maternal and paternal diversity in Xinjiang Kazakh population from China. RUSSIAN JOURNAL OF GENETICS (GENETIKA)，2014，in press. correspondence author.
3. Wang W, Chen K, Liu Q, Johnston N, Ma Z, Zhang F, Zheng X. Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration. PLoS One. 2014 Jul 16;9(7):e102673.  correspondence author.
4. Chen K, Ablimit A, Ling F, Wu W, Shan W, Qin W, Keweier T, Zuo H, Zhang F, Ma Z, Zheng X. Paternal and maternal genetic analysis of a desert Keriyan population: Keriyans are not the descendants of Guge Tibetans. PLoS One. 2014 Jun 26;9(6):e100479.  correspondence author.
5. Zhang X, Liu Y, Zhang G, Shi J, Zhang X, Zheng X, Jiang AT, Zhang ZX, Johnston N, Siu KS, Chen R, Lian D, Koos D, Quan D, Min WP. Synergic silencing of costimulatory molecules prevents cardiac allograft rejection. J Transl Med. 2014 May 22;12:142. doi: 10.1186/1479-5876-12-142.
6. Maleki Vareki S, Rytelewski M, Figueredo R, Chen D, Ferguson PJ, Vincent M, Min W, Zheng X, Koropatnick J. Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin. Oncotarget. 2014 May 15;5(9):2778-91.
7. Siu KS, Chen D, Zheng X, Zhang X, Johnston N, Liu Y, Yuan K, Koropatnick J, Gillies ER, Min WP.Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma.Biomaterials. 2014 Mar;35(10):3435-42.
8. Zhou L, Zang G, Zhang G, Wang H, Zhang X, Johnston N, Min W, Luke P, Jevnikar A, Haig A, Zheng X. MicroRNA and mRNA Signatures in Ischemia Reperfusion Injury in Heart Transplantation. PLoS One. 2013 Nov 20;8(11):e79805. correspondence author.
9. Ablimit A, Qin W, Shan W, Wu W, Ling F, Ling KH, Zhao C, Zhang F, Ma Z, Zheng X. Genetic diversities of cytochrome B in Xinjiang Uyghur unveiled its origin and migration history.BMC Genet. 2013 Oct 9;14:100. correspondence author.
10. Guoyao Zang , Ashley Thomas , Zhongyuan Liu, Di Chen, Hong Ling, Liangyi Zhou, Fuchun Zhang, Leo Siu , Xiufen Zheng*. Preventing breast cancer growth by cationic Cecropin B. Biological Science Open Access, 2013. 2:3. correspondence author.
11. Zheng X, Koropatnick J, Chen D, Velenosi T, Ling H, Zhang X, Jiang N, Navarro B, Ichim TE, Urquhart B, Min WP.Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model. Int J Cancer. 2012 Jul 2. 132(4):967-77. Correspondence author.
12. Sun J, Zheng J, Ling KH, Zhao K, Xie Z, Li B, Wang T, Zhu Z, Patel AN, Min W, Liu K, Zheng X. Preventing Intimal Thickening of Vein Grafts in Vein Artery Bypass Using STAT-3 siRNA. J Transl Med. 2012 Jan 4;10(1):2. [Epub ahead of print] SCI/ IF:3.51. correspondence author.
13. Li Rong, Zheng Xiufen, Igor Popov, Xusheng Zhang, Hongmei Wang, Motohiko Suzuki, Rosalia De Necochea-Campion, Peter W French, Di Chen, Leo Siu, David Koos, Robert D Inman and Wei-Ping Min. Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J. Transl. Medicine, 2012. 10:19. SCI/ IF:3.51.
14. Jiang N, Zhang X, Zheng X, Chen D, Siu K, Wang H, Ichim TE, Quan D, McAlister V, Chen G, Min WP. A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis. PLoS One. 2012;7(9):e44138. Epub 2012 Sep.
15. Zhang X, Beduhn M, Zheng X, Lian D, Chen D, Li R, Siu LK, Marleau A, French PW, Ichim TE, Min WP. Induction of Alloimmune Tolerance in Heart Transplantation Through Gene Silencing of TLR Adaptors. Am J Transplant. 2012 Oct;12(10):2675-88.
16. Jiang N, Zhang X, Zheng X, Chen D, Zhang Y, Siu LK, Xin HB, Li R, Zhao H, Riordan N, Ichim TE, Quan D, Jevnikar AM, Chen G, Min W. Targeted gene silencing of TLR4 using liposomal nanoparticles for preventing liver ischemia reperfusion injury. Am J Transplant. 2011. Sep;11(9):1835-44. doi: 10.1111/j.1600-6143.2011.03660.x. Epub 2011 Jul 27. SCI/ IF:6.200.
17. X Zheng, Motohiko Suzuki, Thomas E. Ichim, Xusheng Zhang, Fei Zhu, Hongtao Sun, Marianne Beduhn, Aminah Shunner, Bertha Garcia, Robert D Inman, and Weiping Min. Treatment of autoimmune arthritis using RNAi-modulated dendritic cells. J Immounology, 2010, Jun 1;184(11):6457-64. Epub 2010 Apr 30. SCI/ IF:6.000.
18. Zheng X, Suzuki M, Zhang X, Ichim TE, Zhu F, Ling H, Shunnar A, Wang MH, Garcia B, Inman RD, Min W. RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis. Arthritis Res Ther. 2010 Jan 26;12(1):R13. [Epub ahead of print] SCI /IF:4.48.
19. Zheng X, Vladau C, Shunner A, Min WP..siRNA specific delivery system for targeting dendritic cells.Methods Mol Biol. 2010;623:173-88.
20. Suzuki M, Zheng X, Zhang X, Zhang ZX, Ichim TE, Sun H, Nakamura Y, Inagaki A, Beduhn M, Shunnar A, Garcia B, Min WP.A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells. J Allergy Clin Immunol. 2010 Mar;125(3):737-43, 743.e1-743.e6. SCI/IF:9.773.
21. Zhang ZX, Beduhn ME, Zheng X, Min WP, Jevnikar AM。 Preventing tissue injury using siRNA. Methods Mol Biol. 2010;623:341-55.
22. Zhang Y, Peng T, Zhu H, Zheng X, Zhang X, Jiang N, Cheng X, Lai X, Shunnar A, Singh M, Riordan N, Bogin V, Tong N, Min WP。 Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4. J Transl Med. 2010 Dec 15;8:133.
23. X Zheng, D Lian, A Wang, TE Ichim, M Khoshniat, M Byruge, X Zhang, H Sun, JC Lacefield, B Garcia, AM Jevnikar, and Wei-Ping Min. A novel siRNA-containing solution protecting donor organs in heart transplantation. Circulation. 2009, Sept22, 2009. (12):1099-107, 1 p following 1107.
24. X Zheng, C Vladau,, X Zhang1, M Suzuki, TE Ichic, Garcia, AM Jevnikar and W-P Min. A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation. Blood. 2009 Mar 19;113(12):2646-54. Epub 2009 Jan 22.
25. Suzuki M, Zheng X, Zhang X, Zhang Y, Ichim TE, Min W. Regulation of allergy with RNA interference. Crit Rev Immunol. 2009;29(6):443-68.

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