Dr. Gilman Siu

Department of Health Technology and Informatics,

The Hong Kong Polytechnic University

Assistant Professor

Email: khsiu@polyu.edu.hk

Qualifications

2010 Ph.D., Microbiology, The University of Hong Kong, Hong Kong

2006 B.Sc., Biomedical Science, The Hong Kong Polytechnic University, Hong Kong

Research Fields

Drug resistance and virulence mechanisms in Mycobacterium tuberculosis

Molecular diagnostics of infectious diseases

Molecular epidemiology of emerging infectious diseases

Publications (selected)

1. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. LanY, Lam JT, Siu GK, Yam WC, Manson AJ, Lam JK. Tuberculosis (Edinb). 2014 [Epub ahead of print] (Impact Factor 3.503)
2. An upstream truncation of furA-katG operon confer high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance associated mutations. Siu GK, Yam WC, Zhang Y, Kao RY. Antimicrob Agents Chemother. 2014 [Epub ahead of print] (Impact Factor 4.451)
3. Evaluation of LightCycler® Methicillin-Resistant Staphylococcus aureus (MRSA) Advanced Test for the detection of nasal colonizing MRSA. Yam WC, Siu GK, Ho PL, Ng TK, Que TL, Yip EK, Fok CP, Chen JH, Cheng VC, Yuen KY. J Clin Microbiol. 2013; 51(9):2869-74 (Impact Factor 4.232)
4. Direct Bacterial Identification in Blood Cultures using two commercial MALDI-TOF mass spectrometry systems. Chen JH, Ho PL, Kwan GS, She KK, Siu GK, Cheng VC, Yuen KY, Yam WC. J Clin Microbiol. 2013; 51(6):1733-9. 51(6):1733-9 (Impact Factor 4.232)
5. Rapid Identification of Mycobacteria and Rapid Detection of Drug Resistance in Mycobacterium tuberculosis in Cultured Isolates and in Respiratory Specimens. Yam WC, Siu KH. Methods Mol Biol. 2013; 943:171-99.(Impact Factor 1.29)
6. Yam WC, Siu GK. Rapid Identification of Mycobacteria and Rapid Detection of Drug Resistance in Mycobacterium tuberculosis in Cultured Isolates and in Respiratory Specimens. In Mark Wilks (ed.), PCR Detection of Microbial Pathogens: Second Edition, Methods in Molecular Biology, vol. 943.2012. Berlin, Germany, Springer Science+Business Media.
7. Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides. Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, Mclntyre CA, Yam WC, Siu GK, Atkinson RA, Lam KW, Bansal SS, Drake AF, Mitchell GH, Mason AJ. J Biol Chem. 2012; 287(41):34120-33. (Impact Factor 4.773)
8. Molecular Characterization of Fluoroquinolone-Resistant Mycobacterium tuberculosis Clinical Isolates from Shanghai ,China. Zhu CY, Zhang YX, Shen YZ, Siu GK, Wu WJ, Qian XQ, Deng GL, Xu Y, Lau RW, Fan XY, Zhang WH, Lu HZ, Yam WC. Diagn Microbiol Infect Dis. 2012; 206(3): 260-3. (Impact Factor 2.528)
9. High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis. Lee AS, Ong DC, Wong JC, Siu GK, Yam WC. PLoS One. 2012;7(2):e31934. (Impact Factor 4.092)
10. Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan and bile salts. Cheng VC, Yam WC, Tsang LL, Yau MC, Siu GK, Wong SC, Chan JF, To KK, Tse H, Hung IF, Tai JW, Ho PL, Yuen KY. J Clin Microbiol. 2012; 50(5):1571-9. (Impact Factor 4.232)
11. Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong. Cheng VC, Yam WC, Lam CT, Siu GK, Chan FW, To KW, Li WS, Tai WM, Ho PL, Yuen KY. Eur J Clin Microbiol Infect Dis. 2011. (Impact Factor 2.859)
12. Mutations outside rifampicin resistance determining region associated with rifampicin resistance in Mycobacterium tuberculosis. Siu GK, Zhang Y, Lau CK, Lau RW, Ho PL, Yew WW, Tsui KW, Cheng VC, Yuen KY Yam WC.J Antimicrob Chemother, 2011. 66, 730-3. (Impact Factor 5.439)
13. Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific PCR. Siu GK, Tam YH, Ho PL, Lee AS, Que TL, Tse WS, Yip KT, Lam TH, Cheng VC, Yuen KY, Yam WC. Diagn Microbiol Infect Dis. 2010. 69, 51-58 (Impact Factor 2.528)
14. Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis. Ong DC, Yam WC, Siu GK, Lee AS. J Clin Microbiol. 2010 Apr;48(4):1047-54. (Impact Factor 4.232)
15. Rapid diagnosis of multidrug-resistant smear-positive pulmonary tuberculosis. Lau RW, Ho PL, Kao RY, Siu GK, Cheng VC, Yuen KY, Yam WC. Int J Antimicrob Agents. 2010 Feb;35(2):202-3. (Impact Factor 4.128)
16. Haracterisation of methicillin-resistant Staphylococcus aureus isolates from dogs and their owners. Boost MV, O'Donoghue MM, Siu KH. Clin Microbiol Infect. 2007 Jul;13(7):731-3 (Impact Factor 4.54)

Profile Details

http://www.polyu.edu.hk/hti/staff/CVs/SIU_Gilman.pdf