Dr. Sabzali Javadov

School of Medicine

University of Puerto Rico, USA

Associate Professor

Email: sabzali.javadov@upr.edu

Qualifications

1992 D.Sc., Cardiology Research Center, Russian Academy of Medical Sciences, and Moscow State University, Cardiac Pathophysiology & Biochemistry

1986 Ph.D., Cardiology Research Center, Russian Academy of Medical Sciences, Cardiology & Biochemistry

1983 M.D., Russian Medical University, Medical Biochemistry

Publications (Selected)

1. Barreto-Torres G, Parodi-Rullan R, Javadov S. (2012) The role of PPARα in metformin-Induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats. International Journal of Molecular Sciences, 13: 7694-7709.
2. Rajapurohitam V, Kilic A, Javadov S, Karmazyn M.(2012) Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy. Molecular & Cellular Biochemistry, 366: 287-97.
3. Parodi-Rullan R, Barreto-Torres G,Louis Ruiz L, Casasnovas J, Javadov S. (2012) Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats. Cellular Physiology & Biochemistry, 29: 841-850.
4. Javadov S. (2012) Mitochondrial permeability transition: known phenomenon with unknown molecular identity (Editorial). Anatomy & Physiology, 2: e117. doi:10.4172/2161-0940.1000e117.
5. Gan TX, Hunter JC, Huang C, Xue J, Rajapurohitam V,Javadov S, Karmazyn M. (2012)Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation. Molecular & Cellular Biochemistry, 363: 323-33.
6. Javadov S, Hunter JC,Barreto-Torres G, Parodi-Rullan R. (2011) Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusionversuscarcinogenesis.Cellular Physiology & Biochemistry, 27:179-190.
7. Zeidan A, Hunter JC, Javadov S, Karmazyn M. (2011)mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy. Molecular & Cellular Biochemistry, 352: 99-108.
8. Javadov S, Rajapurohitam V, Kilić A, Hunter JC, Zeidan A, Said Faruq N, Escobales N, Karmazyn M. (2011) Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Basic Research in Cardiology, 106: 99-109.
9. Hunter JC, Zeidan A, Javadov S, Kilic A, Rajapurohitam V, Karmazyn M. (2009) Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway. Journal of Molecular & Cellular Cardiology, 47: 810-818.
10. Javadov S, Karmazyn M, Escobales N. (2009) Mitochondrialpermeability transition pore opening as a promising therapeutic target in cardiac diseases. Journal of Pharmacology & Experimental Therapy, 330: 670-678.
11. Javadov S, Rajapurohitam V, Kilic A, Zeidan A, Choi A, Karmazyn M. (2009) Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3β-dependent attenuation of mitochondrial dysfunction. Journal of Molecular & Cellular Cardiology, 46: 998-1007.
12. Kilic A, Javadov S, Karmazyn M. (2009) Estrogen exerts concentration- dependent pro- and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.Journal of Molecular & Cellular Cardiology, 46: 360-369.
13. Karmazyn M, Kilic A, Javadov S. (2008)The role of NHE‑1 in myocardial hypertrophy and remodelling.Journal of Molecular & Cellular Cardiology, 44: 647-653.
14. Javadov S,Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M. (2008) NHE-1 inhibition-induced cardioprotection against ischemia/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovascular Research, 77: 416-424.
15. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M. (2008) Leptin–induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCKdependent p38 MAPK translocation to nuclei. Cardiovascular Research, 77: 64-72.
16. Zeidan A, Payler B, Steinhoff K, Javadov S, Rajapurohitam R, Chakrabarti S, Karmazyn M. (2007) Actin cytoskeleton dynamics promote leptin-induced vascular smooth muscle hypertrophy via Rho/ROCKand PI3K/Akt dependent pathways. Journal of Pharmacology & Experimental Therapy, 322: 1110-1116.
17. Javadov S, Karmazyn M. (2007) Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cellular Physiology & Biochemistry, 20:1-22.
18. Xia Y, Javadov S, Gan TX, Pang T, Cook MA, Karmazyn M. (2007) Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes. Journal of Pharmacology & Experimental Therapy, 320: 14-21.
19. Javadov S, Purdham DM, Zeidan A, Karmazyn M. (2006) NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodelling. American Journal Physiology (Heart & Circulatory Physiology), 291: H1722-30.
20. Zeidan A, Javadov A, Karmazyn M. (2006) Essential role of Rho/ROCKdependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes. Cardiovascular Research, 72: 101-11.

Last Updated: August, 2012