Dr. Jianxun (Jim) Song

Dept. of Microbiology & Immunology Penn State

University College of Medicine, USA

Associate Professor

Email: songjianxun@yahoo.com (preferred), jus35@psu.edu

Qualifications

2001 Ph.D., The Third Military Medical University, China

1993 M.Sc., The Third Military Medical University, China

1989 B.Sc., Chongqing University, China

Research Fields

Immunology

Cell Biology

Publications (Selected)

1. Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lend SM, Croft M and Song J (2013). Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol, 43 (7): 1914-1924. PMCID: PMC3876962
2. Lei F, Song J, Haque R, Xiong X, Fang D, Croft M and Song J (2013). Regulation of A1 by OX40 contributes to CD8 T cell survival and anti-tumor activity. PLoS One, 8(8): e70635. PMCID: PMC3731243
3. Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y and Song J (2012). Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol 189 (3): 1228-1236. PMCID: PMC3401327
4. Lei F, Haque R, Xiong X, and Song J (2012). Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J Vis Exp. (63), e3986. PMCID: PMC3389997
5. Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, and Fang D (2012). USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development. Mol Cell, 46(4): 484-494. PMID: 22542455
6. Lei F, Haque R, Xiong X, Budgeon L, Christensen ND, Wu Y and Song J (2011). In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res, 71(14): 4742-4747. PMID: 21628492
7. Tian Y, Jia Z, Wang J, Huang Z, Tang J, Zheng Y, Tang Y, Wang Q, Tian Z, Yang D, Zhang Y, Fu X, Song J, Liu S, van Velkinburgh JC, Wu Y, Ni B (2011). Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One. 2011; 6(11):e27770. PMID: 22132139
8. Haque R, Lei F, Xiong X, and Song J (2011). The regulation of FoxP3-expressing regulatory T cells. Endocr Metab Immune Disord Drug Targets, 11: 334-336. PMID: 21696363
9. Haque R, Lei F, Xiong X, Wu Y, and Song J (2010). FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther 12(2): R66. PMID 19454669
10. Lei F, Haque R, Weiler L, Vrana KE, and Song J (2009). T lineage differentiation from induced pluripotent stem cells. Cell Immunol 260 (1): 1-5. PMID 19811778
11. Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, and Song J (2009). Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol 182 (11): 6744-6752. PMID 19454669 5
12. Song J, So T and Croft M (2008). Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol 180(11): 7240-7248. PMCID: PMC2410213
13. Song J, Lei F, Xiong X and Haque R (2008). Intracellular signals of T cell costimulation. Cell Mol Immunol 5 (4): 239-247. PMID 18761811
14. Song J, Salek-Ardakani S, So T, and Croft M (2007). The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol 8 (1): 64-73. PMID: 17128276
15. Song A, Song J, Tang X, Croft M (2007). Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5): 1224-1232. PMID 17429847
16. So T, Song J, Sugie K, Altman A, and Croft M (2006). Signals from OX40 regulate NFATc1 and Th2 lineage commitment. Proc Natl Acad Sci U S A 103(10): 3740-3745. PMCID: PMC1450148
17. Song J, So T, Cheng M, Tang X and Croft M (2005). Sustained Survivin expression from OX40 costimilatory signals drives T cell clonal expansion. Immunity 22(5): 621-631. PMID 15894279
18. Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A (2005). Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8): 5126-5134. PMID: 16210616
19. Song J, Salek-Ardakani S, Rogers PR, Cheng M, Parijs LV, and Croft M (2004). The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 4(2): 150-158. PMID 14730361
20. Lawson BR, Baccala R, Song J, Croft M, Kono DH, Theofilopoulos AN (2004). Deficiency of the Cyclin Kinase Inhibitor p21 (WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells and Inhibits Spontaneous Systemic Autoimmunity. J Exp Med 199(4): 547-557. PMCID: PMC2194076
21. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M (2003). OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 198(8): 315-324. PMCID: PMC2194076
22. Rogers PR1, Song J1, Gramaglia I, Killeen N and Croft M (2001). OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 14(9): 445-455 (1: joint first authorship). PMID 19454669 (There are additional 20 research papers published in non-English journals)

Profile Details

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