Prof. Mohamed Chahine

Laval University, Canada

Professor

Email: mohamed.chahine@phc.ulaval.ca

Qualifications

1984-1987 Ph.D., Cardiac Cellular and Molecular Biology

1982-1983 M.Sc., Animal Physiology

Publications (Selected)

1. Chahine M., Bibikova A., Sculptoreanu A. (1996). Okadaic acid enhances prepulse facilitation of cardiac-subunit but not endogenous calcium channel currents in Xenopus laevis oocytes. Can J Physiol Pharmacol. 74: 1149-1156.
2. Chahine M., Deschênes I., Chen L.Q., Kallen R.G. (1996). Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels expressed in tsA201 cells. Am J Physiol . 40: H 498-H 506.
3. Marcotte P., Chen L.Q., Kallen R.G., Chahine M. (1997). Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Nachannels. Circ Res. 80: 363-369.
4. Deschênes I., Chahine M., Tremblay J., Paulin D., Puymirat J. (1997). Increase in the proliferative capacity of human myoblasts by using the T antigen under the vimentin promoter control. Muscle Nerve. 20: 437-445.
5. Sauvé R., Diarra A., Chahine M., Simoneau C., Morier N., Roy G. (1991). oscillations induced by histamine receptor stimulation in HeLa cells: Fura-2 and patch clamp analysis. Cell calcium. 12: 165-176.
6. Gellens M.E., George A.L., Jr., Chen L.Q., Chahine M., Horn R., Barchi R.L., Kallen R.G. (1992). Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci USA. 89: 554-558.
7. Chahine M., Chen L.Q., Kallen R.G., Barchi R.L., Horn R. (1992). Expressed Na channel clones differ in their sensitivity to external calcium concentration. Biophys J. 62: 37-40.
8. Chahine M., Chen L.Q., Barchi R.L., Kallen R.G., Horn R. (1992). Lidocaine block of human heart sodium channels expressed in Xenopus oocytes. J Mol Cell Cardiol. 24: 1231-1236.
9. Chen L.Q., Chahine M., Kallen R.G., Barchi R.L., Horn R. (1992). Chimeric study of sodium channels from rat skeletal and cardiac muscle. FEBS Lett. 309: 253-257.
10. Chahine M., George A.L., Jr., Zhou M., Ji S., Sun W., Barchi R.L., Horn R. (1994). Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron. 12: 281-294.
11. Chahine M., Bennett P.B., George A.L., Jr., Horn R. (1994). Functional expression and properties of the human skeletal muscle sodium channel. Pflügers Arch. 427: 136-142.
12. Chahine M., Chen L.Q., Fotouhi N., Walsky R., Fry D., Santarelli V., Horn R., Kallen R.G. (1995). Characterizing the μ-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations. Receptors Channels. 3: 161-174.
13. Chahine M., Plante E., Kallen R.G. (1996). Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cells. J Membr Biol. 152: 39-48.
14. Chahine M., Bibikova A., Sculptoreanu A. (1996). Okadaic acid enhances prepulse facilitation of cardiac-subunit but not endogenous calcium channel currents in Xenopus laevis oocytes. Can J Physiol Pharmacol. 74: 1149-1156.
15. Chahine M., Deschênes I., Chen L.Q., Kallen R.G. (1996). Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels expressed in tsA 201 cells. Am J Physiol . 40: H 498-H 506.
16. Marcotte P., Chen L.Q., Kallen R.G., Chahine M. (1997). Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Nachannels. Circ Res. 80: 363-369.
17. Deschênes I., Chahine M., Tremblay J., Paulin D., Puymirat J. (1997). Increase in the proliferative capacity of human myoblasts by using the T antigen under the vimentin promoter control. Muscle Nerve. 20: 437-445.
18. Chahine M., Deschênes I., Trottier E., Chen L.Q., Kallen R.G. (1997). Restoration of fast inactivation in an inactivation-defective human heart sodium channel by the cysteine modifying reagent benzyl-MTS: Analysis of IFM-ICM 19. mutation. Biochem Biophys Res Commun. 233: 606-610.
19. Chahine M., George A.L., Jr. (1997). Myotonic dystrophy kinase modulates skeletal muscle but not cardiac voltage-gated sodium channels. FEBS Lett. 412: 621-624.

Last Updated: August, 2012